Research Topic: triterpenes

Functional Components from the Liquid Fermentation of Edible and Medicinal Fungi and Their Food Applications in China

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Mushroom mycelium grown in liquid fermentation produces many beneficial compounds like polysaccharides and proteins that support immune function and may help fight cancer and oxidative stress. These fermented mushroom products can be added to foods, beverages, and health supplements to boost their nutritional value and health benefits. Studies show that fermented mushroom mycelium sometimes contains higher levels of beneficial compounds compared to whole mushroom fruiting bodies, making it a promising ingredient for functional foods and health products.

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Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders

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Researchers used computer analysis and laboratory experiments to understand how a medicinal mushroom called Ganoderma lucidum (reishi) helps improve memory and learning problems. They identified ten key active ingredients in the mushroom that work together to reduce inflammation in the brain and protect nerve cells. The most important ingredient appears to be a compound called β-sitosterol, which helps prevent memory loss similar to effects seen in Alzheimer’s disease.

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Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer

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This review explores how two medicinal mushrooms traditionally used in Asian medicine—Lingzhi and Yunzhi—can enhance the effectiveness of lung cancer drugs (EGFR-TKIs) and help overcome drug resistance. These mushrooms contain special compounds that can fight cancer in multiple ways, boost the immune system, and reduce side effects. The research suggests that combining these mushrooms with standard cancer treatments may improve outcomes for lung cancer patients.

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Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens

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This study examined chaga mushroom, a traditional medicine used against cancer, grown on two types of birch trees. Researchers tested chaga extracts on 31 different cancer cell types and found they were moderately effective at inhibiting cancer cell growth, particularly against liver and thyroid cancers. The chaga from silver birch (B. pendula) worked slightly better than that from downy birch (B. pubescens) due to higher levels of a compound called inotodiol.

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Research on the Action and Mechanism of Pharmacological Components of Omphalia lapidescens

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Omphalia lapidescens, a medicinal fungus used in traditional Chinese medicine, contains multiple bioactive compounds with promising health benefits. These compounds can fight parasitic infections, inhibit cancer cell growth, reduce inflammation, and provide antioxidant protection. While clinical use shows benefits especially for gastric cancer when combined with chemotherapy, more research is needed to understand how these compounds work and to improve cultivation and production methods.

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Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

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Ganoderma, a medicinal fungus used in traditional medicine for over 2000 years, contains many beneficial compounds including triterpenes and polysaccharides. Scientific research has confirmed its effectiveness in treating various conditions including cancer, diabetes, infections, and inflammation. The fungus works by boosting the immune system, reducing oxidative stress, and directly inhibiting disease-causing organisms. Modern cultivation methods have made Ganoderma products widely available as supplements and medicines worldwide.

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Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

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Scientists studied how a special fungal treatment can boost the production of beneficial compounds in sanghuang mushrooms. Using advanced molecular analysis techniques, they found that the fungal elicitor significantly increased levels of healing compounds called triterpenes. The treated mushrooms produced 114 times more of one specific compound compared to untreated mushrooms. This research shows how we can grow medicinal mushrooms with higher levels of beneficial substances, which could help develop better treatments for various diseases.

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