Scientists successfully determined the three-dimensional structure of flocculosin-A, a powerful antifungal compound produced by a fungus called Anthracocystis flocculosa. The main challenge was that the compound naturally forms very thin, needle-like crystals unsuitable for analysis. By using a special cooling and heating cycle, researchers were able to grow better crystals and use X-ray diffraction to reveal the compound’s complete molecular structure, which contains a sugar backbone connected to two fatty acid chains with specific arrangements.