Research Topic: SQLE gene mutations

Trichophyton indotineae Infection, São Paulo, Brazil, 2024

A businessman from São Paulo, Brazil contracted a difficult-to-treat fungal skin infection caused by Trichophyton indotineae, which is resistant to the common antifungal drug terbinafine. After terbinafine failed to help over 9 weeks, doctors switched him to itraconazole, which worked well after 8 weeks. Genetic testing showed his fungal strain had a specific resistance mutation and was most similar to a strain from Germany, suggesting he may have caught it while traveling in Europe.

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Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

Researchers in Thailand identified five patients with a new type of fungal skin infection caused by Trichophyton indotineae, a species that resists the common antifungal drug terbinafine. These infections appeared as rashes on various parts of the body and required treatment with alternative medications like itraconazole. The findings represent the first confirmed cases in Thailand and suggest this resistant fungus may be spreading globally. The study also showed that a simple urease test could help doctors identify this resistant strain quickly without waiting for complex genetic testing.

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