prefrontal cortex – mycolab.ai

High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

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This study shows that eating a high-fat diet during the teenage years can harm brain development and mood in mice. The research found that high-fat diets led to anxiety and depression-like symptoms, along with shrinking brain structures and overactive immune cells in the brain. These findings suggest that teenagers should maintain healthy eating habits, as poor diet during adolescence may have long-lasting effects on mental health.

Cell adhesion presence during adolescence controls the architecture of projection-defined prefrontal cortical neurons and reward-related action strategies later in life

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During teenage years, the brain undergoes important structural changes that set the stage for adult decision-making abilities. This study found that a cell adhesion protein called β1-integrin plays a critical role during adolescence in stabilizing connections between brain cells in the prefrontal cortex. When this protein was missing during the teenage years, adult mice struggled to make good decisions about rewards and could not adjust their behavior when circumstances changed. The research suggests that proper brain development during adolescence requires these cellular adhesion molecules to build the neural circuits needed for intelligent decision-making later in life.

Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy

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Researchers used advanced microscopy techniques to examine brain tissue from rats with Alzheimer’s disease and compared it to healthy rats. They found that Alzheimer’s disease causes damage to connections between brain cells (synapses) in a brain region important for thinking and memory. Specifically, the connections were weaker and smaller, and many new spine-like structures formed but didn’t properly connect to other cells, suggesting the brain may be trying unsuccessfully to compensate for the disease.

Research Topic: prefrontal cortex

High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

Cell adhesion presence during adolescence controls the architecture of projection-defined prefrontal cortical neurons and reward-related action strategies later in life

Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy