Research Topic: prebiotics

Exploring the Prebiotic Potentials of Hydrolyzed Pectins: Mechanisms of Action and Gut Microbiota Modulation

Pectins are fiber-like compounds found in fruits and vegetables that can benefit gut health by feeding beneficial bacteria. When pectins are broken down into smaller pieces (oligosaccharides), they work better as prebiotics, promoting the growth of healthy gut bacteria that produce beneficial substances called short-chain fatty acids. These compounds may help improve digestive health, strengthen immunity, and reduce inflammation.

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Maternal Euglena gracilis supplementation alters sow and piglet gut microbiota, reduces diarrhea incidence, and enhances piglet growth

This study examined how feeding sows a supplement called Euglena gracilis (an algae-derived prebiotic) affected the gut bacteria of both the sows and their piglets. Piglets born to supplemented sows weighed more at weaning and had fewer cases of diarrhea during the nursing period. The supplement changed the types of bacteria in both the sows’ and piglets’ guts in beneficial ways, promoting healthier and more stable gut communities that supported better growth and digestive health.

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Microbiota-based interventions for autism spectrum disorder: a systematic review of efficacy and clinical potential

This comprehensive review examines how modifications to gut bacteria through probiotics, prebiotics, synbiotics, and fecal transplants can help children with autism. The research found that while all these treatments showed some promise, fecal microbiota transplantation (FMT) produced the most consistent improvements in both autism-related behaviors and digestive symptoms. These microbiota-based approaches work through the gut-brain connection and were generally safe, making them potentially valuable additions to autism management strategies.

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In-ovo injection of Bacillus subtilis, raffinose, and their combinations enhances hatchability, gut health, nutrient transport- and intestinal function-related genes, and early development of broiler chicks

Researchers injected newly developing chicken eggs with beneficial bacteria (Bacillus subtilis) and a prebiotic substance (raffinose) to improve chick health. The treatment enhanced egg hatchability, improved chick weight, reduced harmful bacteria in the gut, and strengthened intestinal function. This approach shows promise as a natural alternative to antibiotics in poultry farming.

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Modulation of gut microbiome in response to the combination of Escherichia coli Nissle 1917 and sugars: a pilot study using host-free system reflecting impact on interpersonal microbiome

This study examined how a beneficial bacteria called Escherichia coli Nissle 1917 combined with different types of sugar affects gut bacteria. Researchers found that the effectiveness of these treatments depends heavily on each person’s unique starting microbiota composition, which is shaped by their diet, lifestyle, and health status. The results show that one-size-fits-all probiotic treatments don’t work equally for everyone, and doctors should personalize treatments based on an individual’s existing gut bacteria profile.

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Nutritional strategies in supporting immune checkpoint inhibitor, PI3K inhibitor, and tyrosine kinase inhibitor cancer therapies

This review examines how nutrition and food-based interventions can improve cancer treatment outcomes for patients receiving targeted cancer therapies. A Mediterranean-style diet with plenty of fiber (30-50g daily) appears beneficial for patients on immune checkpoint inhibitor therapies by promoting healthy gut bacteria that support immune function. The review also discusses promising research on fermented foods, specific bacterial supplements, mushroom extracts, and fasting approaches as complementary strategies to enhance cancer treatment effectiveness while reducing side effects.

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Unveiling roles of beneficial gut bacteria and optimal diets for health

Your gut bacteria are tiny living organisms that help digest food, support your immune system, and influence your overall health. Eating foods rich in fiber, fermented products like yogurt and kimchi, and colorful fruits and vegetables helps grow these beneficial bacteria. When your gut bacteria become unbalanced, it can lead to inflammation and various diseases, but eating the right foods can restore balance and improve your health.

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Effects of dietary Fibrafid as phytogenic supplementation in standard and nutrient-reduced diets on breast meat quality, carcass traits, histopathology, and feed efficiency in heat-stressed broilers

This research tested a plant-based feed additive called Fibrafid in broiler chickens raised in hot conditions. When included at 0.25% in their diet, Fibrafid improved meat quality by increasing its ability to retain moisture and enhancing tenderness, while also supporting growth even when using lower-nutrition diets. The additive maintained healthy intestines and improved feed efficiency, offering a practical and sustainable solution for poultry farmers in hot climates.

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How Do Cyclodextrins and Dextrans Affect the Gut Microbiome? Review of Prebiotic Activity

Cyclodextrins and dextrans are substances commonly used in medicines that may have unexpected health benefits for your gut bacteria. Research shows these compounds can help beneficial bacteria like Lactobacillus and Bifidobacterium grow better in your digestive system. When these good bacteria ferment these substances, they produce helpful compounds called short-chain fatty acids that improve overall gut health and may help with conditions like obesity and inflammation.

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