oxidative stress – Page 3

The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease

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This comprehensive review examines how traditional Chinese medicine ingredients can treat fatty liver disease through multiple biological pathways simultaneously. Unlike conventional drugs that target a single pathway, TCM compounds address the complex, interconnected causes of the disease including fat accumulation, inflammation, and tissue damage. The research identifies dozens of effective herbal compounds and proposes a new framework for designing TCM treatments tailored to individual patient needs.

Neuroprotective Effects of Mushroom Biomass Digestive Fractions and Gut Microbiota Metabolites in Microglial and Caenorhabditis elegans Models of Neurodegeneration

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This study tested whether common and medicinal mushrooms could protect against Alzheimer’s disease by reducing harmful reactive oxygen species in brain cells. Researchers tested three mushroom types using digestive simulation to see what the body could absorb, plus key compounds made by gut bacteria. The mushroom extracts and certain bacterial metabolites successfully reduced cellular damage markers and improved behavior in disease-model worms, suggesting mushroom-rich diets may help prevent neurodegeneration.

The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury

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This research demonstrates that polysaccharides extracted from Ganoderma lucidum mushrooms can protect rat retinas from damage caused by blocked and then restored blood flow. The treatment reduced cell death, decreased harmful oxidative stress, reduced inflammation-like responses from support cells, and improved retinal electrical function. These findings suggest that Ganoderma lucidum could potentially be developed as a therapeutic option for eye diseases like glaucoma and diabetic retinopathy where blood flow to the retina is compromised.

Synergistic inhibition of Aspergillus flavus by organic acid salts: growth, oxidative stress, and aflatoxin gene modulation

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A dangerous fungus called Aspergillus flavus contaminates animal feed and produces harmful toxins called aflatoxins that can make animals sick. Researchers tested a combination of three salt-based organic acids commonly used as natural food preservatives and found they work together to kill this fungus much better than using them individually. The combination damages the fungus’s cell structure, creates harmful reactive oxygen inside the cells, and shuts down the genes that produce the toxins, making it an excellent safe option for protecting animal feed.

The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts

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Different recipes made from Ganoderma lucidum mushroom have different health benefits. This study tested two recipes in mice and found that one (PGB) was better for reducing fatigue and improving exercise performance, while the other (GBS) was better for improving sleep quality. The research shows that how you prepare and combine medicinal mushroom ingredients matters for what health benefits you get.

Potential of Wormwood and Oak Bark-Based Supplement in Health Improvement of Nosema ceranae-Infected Honey Bees

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This study tested a natural dietary supplement made from wormwood and oak bark on honey bees infected with Nosema ceranae, a parasite that weakens bee colonies. The supplement significantly improved bee survival and reduced parasite levels, regardless of when it was given. It also reduced harmful oxidative stress caused by the infection. While it didn’t boost immune genes as strongly as some other treatments, its plant-based nature and consistent effectiveness make it a promising tool for beekeepers.

Integrated Transcriptomics and Metabolomics Provide Insight into Degeneration-Related Molecular Mechanisms of Morchella importuna During Repeated Subculturing

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Morel mushrooms are prized edible fungi that unfortunately degrade when repeatedly cultured in the laboratory, becoming slower-growing and less productive. Researchers used advanced genetic and chemical analysis to discover that degeneration occurs when the mushroom stops producing flavonoids, natural antioxidants that protect cells from damage. A specific gene called NR-PKS is responsible for making these protective flavonoids, and it shuts down in degraded strains. The study suggests that preservation methods using cold storage or adding antioxidants could help maintain healthy, productive morel cultures.

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review

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Spinocerebellar ataxia type 3 is a serious brain disease that causes movement problems and gets worse over time. Current medications help but often have unpleasant side effects. This review examined fifteen traditional Chinese herbal remedies that show promise in protecting nerve cells from damage caused by oxidative stress, a harmful chemical process in the body. These herbs work through multiple protective mechanisms and may eventually be tested in patients.

Response to Salt Stress of the Halotolerant Filamentous Fungus Penicillium chrysogenum P13

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Scientists studied a special salt-loving fungus called Penicillium chrysogenum P13 that can survive in very salty environments like salt lakes. When exposed to high salt levels, the fungus activates protective mechanisms including special enzymes that neutralize harmful cellular damage. The research shows that the fungus handles salt stress by producing more of its own antioxidants and storing special compounds that protect its cells.

The Therapeutic Effect and Mechanism of Traditional Chinese Medicine in Type 2 Diabetes Mellitus and Its Complications

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Traditional Chinese Medicine uses various herbs and plant compounds to treat Type 2 diabetes by improving how the body controls blood sugar and protects the pancreas. Many common TCM herbs like ginseng, rehmannia, and coptis work through natural mechanisms that reduce inflammation, protect cells from damage, and improve how the body uses insulin. Research shows TCM may also help prevent or reduce diabetes-related complications affecting the eyes, kidneys, and nerves. These herbal treatments offer potential benefits with fewer side effects compared to conventional medications.

Research Topic: oxidative stress