Research Topic: onychomycosis treatment

Combination of Q-switched 1,064 and 532 nm Nd: YAG laser in the treatment of toenail onychomycosis: a pilot study

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This study tested a laser treatment using two different wavelengths (1,064 and 532 nanometers) to treat toenail fungal infections. Fifteen patients with toenail fungus received eight weekly laser sessions. The treatment was safe and worked best for mild cases, curing 100% of them, but was less effective for severe infections. Although patients experienced some pain during treatment, the overall results suggest laser therapy could be a useful option for treating mild fungal toenail infections without the side effects of oral medications.

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Safety and efficacy of the swift microwave device in patients with mild-to-moderate onychomycosis: Protocol of an open-label, randomized, dose-finding pilot study

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Onychomycosis, commonly known as toenail fungus, is a widespread infection affecting millions of people. Current treatments often fail or cause side effects. This study tests a new microwave device that heats the infected nail to kill the fungus without harming surrounding tissue or causing systemic side effects. Researchers are testing three different treatment schedules to find the most effective approach.

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Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens

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Researchers discovered that hydrogen sulphide (H2S), a small gas molecule, can effectively kill the fungi and bacteria that cause painful nail infections. Unlike current treatments that struggle to penetrate into the nail, hydrogen sulphide easily diffuses through the nail plate. The study found that H2S works by damaging the fungi’s respiratory system and creating harmful reactive oxygen species, while also modifying proteins in a way that disrupts their normal function. This innovative approach could offer patients a new topical treatment option for nail infections that have been difficult to treat with existing medications.

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Safety and Efficacy of a 48-Month Efinaconazole 10% Solution Treatment/Maintenance Regimen: 24-Month Daily Use Followed by 24-Month Intermittent Use

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Researchers studied a 4-year treatment plan for toenail fungal infections using efinaconazole, an antifungal solution applied daily for 2 years, then 2-3 times weekly for another 2 years. The treatment was safe and effective, with all patients who achieved a cure maintaining it through the maintenance phase, and even some non-cured patients improving further. The study included many elderly patients, showing the treatment is safe across all age groups and could help prevent infection relapse.

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