Research Topic: mycotherapy

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

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This comprehensive review examines how medicinal mushrooms contain natural compounds that can boost immune function, fight cancer cells, reduce inflammation, and protect nerve cells. Different mushroom species like reishi, shiitake, and maitake contain various active substances such as beta-glucans and triterpenes that work through multiple biological pathways. While laboratory and animal studies show promising results, more human clinical trials are needed to confirm effectiveness and establish safe dosing guidelines.

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Nutritional strategies in supporting immune checkpoint inhibitor, PI3K inhibitor, and tyrosine kinase inhibitor cancer therapies

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This review examines how nutrition and food-based interventions can improve cancer treatment outcomes for patients receiving targeted cancer therapies. A Mediterranean-style diet with plenty of fiber (30-50g daily) appears beneficial for patients on immune checkpoint inhibitor therapies by promoting healthy gut bacteria that support immune function. The review also discusses promising research on fermented foods, specific bacterial supplements, mushroom extracts, and fasting approaches as complementary strategies to enhance cancer treatment effectiveness while reducing side effects.

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Mushroom-Based Supplements in Italy: Let’s Open Pandora’s Box

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Researchers tested 19 mushroom supplement products sold in Italy and found serious quality problems. Many supplements didn’t actually contain the mushroom species listed on their labels. Some products also contained toxic substances or inconsistent amounts of beneficial compounds. The study highlights the need for better regulation and manufacturing standards to ensure these popular health products are safe and effective.

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Exploring Psilocybe spp. mycelium and fruiting body chemistry for potential therapeutic compounds

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This study analyzed the chemical composition of ‘magic mushrooms’ (Psilocybe) at different growth stages—liquid cultures, grain cultures, and mature fruiting bodies. Using advanced laboratory techniques, researchers found that fruiting bodies contain the highest levels of psilocybin (the psychoactive compound), while mycelium contains unique beneficial compounds like alpha-glycerylphosphorylcholine that may have therapeutic value without strong psychedelic effects. The findings suggest that Psilocybe mycelium could be developed as a non-intoxicating health supplement with potential therapeutic applications.

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