Research Topic: mushroom bodies

Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila

Scientists discovered that fruit flies store memories using postsynaptic changes at cholinergic synapses, similar to how humans use postsynaptic mechanisms at glutamate synapses. Specific acetylcholine receptor subunits (α5 and α2) in brain cells called M4/6 neurons are required for different stages of memory formation. The research shows that fundamental memory storage mechanisms are conserved across evolution despite differences in the chemical messengers used.

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The Neural Signature of Visual Learning Under Restrictive Virtual-Reality Conditions

Scientists studied how honey bees learn to distinguish different colors in a virtual reality environment. By examining the brains of bees that successfully learned versus those that didn’t, researchers found that successful learning caused specific genes to be turned down in key visual brain regions. This suggests that learning involves not just turning genes on, but also turning some off, which may help the brain focus on important visual information. The findings help us understand how animal brains process visual information and learn from experience.

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