Research Topic: mood disorders

Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls

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This study followed nearly 1000 people who microdose psilocybin (small regular doses of psilocybin mushrooms) and compared them to 180 people who don’t microdose over one month. Microdosers showed greater improvements in mood, depression, anxiety, and stress compared to the control group. Interestingly, when older adults combined psilocybin with lion’s mane mushrooms and niacin, they showed better improvements in motor control and speed. The effects were fairly consistent across different ages and genders, suggesting psilocybin microdosing may have real benefits for mental health.

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The Potential Role of Psilocybin in Traumatic Brain Injury Recovery: A Narrative Review

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This review examines how psilocybin, a compound found in certain mushrooms, may help people recover from traumatic brain injuries. The research suggests that psilocybin could reduce harmful inflammation in the brain, help the brain form new connections to compensate for damage, and improve mood and depression commonly experienced after brain injuries. While promising, the authors emphasize that more clinical trials are needed to confirm safety and effectiveness before psilocybin can be used to treat brain injury patients.

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Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression

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This research study is investigating how psilocybin, a compound from certain mushrooms, affects the brain in people with depression. The study involves 50 participants who will receive either psilocybin or a placebo, with their brain activity monitored using advanced imaging scans. Researchers will examine how psilocybin changes blood flow and network activity in brain regions involved in mood regulation, and whether these changes are linked to improvements in depression symptoms.

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High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

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This study shows that eating a high-fat diet during the teenage years can harm brain development and mood in mice. The research found that high-fat diets led to anxiety and depression-like symptoms, along with shrinking brain structures and overactive immune cells in the brain. These findings suggest that teenagers should maintain healthy eating habits, as poor diet during adolescence may have long-lasting effects on mental health.

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Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review

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Lion’s Mane mushroom shows promising benefits for brain health, potentially improving memory and reducing symptoms of anxiety and depression. It may help prevent cancer by triggering cancer cell death and supports digestive health by promoting beneficial gut bacteria. While generally safe, some people experience mild side effects like stomach discomfort or headaches, making it an accessible supplement for overall wellness.

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