Research Topic: metabolic flexibility

Structural and functional characterisation and regulatory mechanisms of SWI/SNF and RSC chromatin remodelling complexes in fungi

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This review examines special protein complexes called SWI/SNF and RSC that help fungi control their genes by rearranging DNA packaging. These complexes are important for fungal survival under stress and for causing disease. The researchers compared these complexes across different fungal species and found both similarities and differences that could help scientists develop new antifungal medicines.

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Is metabolic generalism the Breakfast of Champions for pathogenic Candida species?

mycolabadmin

This review examines how different Candida species, including the common cause of yeast infections (C. albicans) and the more dangerous bloodstream pathogen (C. glabrata), survive in the human body. While most pathogenic Candida species are metabolic generalists that can eat many different nutrients, the review shows that C. glabrata is a specialist that has found alternative strategies to thrive. Understanding these metabolic strategies is important for developing better treatments and fighting antifungal resistance.

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