Medicinal – Page 55

Recalled childhood trauma and post-psychedelic trajectories of change in a mixed-methods study

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This study examined how childhood trauma can resurface during psychedelic experiences and what happens afterward. Researchers surveyed over 600 people who had difficult experiences after using psychedelics, and interviewed 18 of them in detail. They found that trauma surfaced in different ways—some people vividly relived events, others felt intense bodily sensations, and some experienced confusion. About half of participants found healing from the experience, while others struggled with ongoing trauma symptoms or mixed outcomes. The research emphasizes the importance of proper preparation, supportive settings, and follow-up integration work to help people process these experiences safely.

The Effect of Combined Treatment of Psilocybin and Eugenol on Lipopolysaccharide-Induced Brain Inflammation in Mice

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This study tested whether psilocybin (an active compound from magic mushrooms) combined with eugenol (a natural compound from cloves) could reduce brain inflammation in mice. Researchers gave mice a substance that triggers inflammation in the brain and then treated them with these compounds before or after the inflammation started. The combination treatment, especially at a 1:50 ratio of psilocybin to eugenol, significantly reduced multiple inflammatory markers in the brain, suggesting this combination could potentially be helpful for treating brain inflammation-related conditions.

Anti-Hyperlipidemic and Anti-Atherogenic Effect of Citrus Peel Pectin Against Cholesterol and Cholic Acid Induced Hyperlipidemia in Sprague Dawley Rats

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Researchers tested whether pectin extracted from citrus peels could help treat high cholesterol and fat levels in the blood using rats. When rats were given different amounts of citrus peel pectin mixed into their food, their cholesterol and triglyceride levels decreased significantly while their good cholesterol (HDL) increased. The treatment also protected their heart, liver, and kidney tissues from damage. This suggests citrus peel pectin, usually thrown away by juice companies, could become a useful and natural remedy for managing high cholesterol.

Upcycled Orange Peel Ingredients: A Scoping Review on Phytochemical Composition, Extraction Techniques, and Biorefinery Strategies

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Orange peels, which make up half the weight of oranges, are usually thrown away but contain valuable compounds beneficial for health. Scientists have found that these peels are rich in phytochemicals that can reduce inflammation, improve heart health, and support gut health. New methods are being developed to extract and use these beneficial compounds in food products, creating a more sustainable and waste-free approach to the citrus industry.

Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer

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This review explores how two medicinal mushrooms traditionally used in Asian medicine—Lingzhi and Yunzhi—can enhance the effectiveness of lung cancer drugs (EGFR-TKIs) and help overcome drug resistance. These mushrooms contain special compounds that can fight cancer in multiple ways, boost the immune system, and reduce side effects. The research suggests that combining these mushrooms with standard cancer treatments may improve outcomes for lung cancer patients.

An implementation framework for evaluating the biocidal potential of essential oils in controlling Fusarium wilt in spinach: from in vitro to in planta

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Researchers tested four common essential oils (thyme, oregano, marjoram, and tea tree) to see if they could stop a dangerous fungal disease in spinach plants. They found that thyme and oregano oils worked best at killing the fungus in laboratory tests and when applied to spinach seeds in the greenhouse, with thyme oil reducing disease by over half without harming the plants.

Dietary Intake of Phytochemicals, Gut Microbiota, and Appetite Control

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This research editorial highlights how plant-based foods rich in phytochemicals can improve gut health by promoting beneficial bacteria growth and supporting communication between the gut and brain. These dietary interventions show promise in helping control appetite, improve metabolism, and reduce the risk of diseases like obesity and type 2 diabetes. The studies suggest that personalized nutrition approaches based on individual microbiome profiles could offer more effective disease prevention and health maintenance strategies.

Feasibility of the use of Lentinula edodes mycelium in terbinafine remediation

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Scientists tested whether shiitake mushrooms (Lentinula edodes) could remove terbinafine, a common antifungal medication, from contaminated environments. The mushroom mycelium successfully accumulated and broke down the drug into harmless byproducts, with no trace remaining in the surrounding medium. This eco-friendly approach offers a promising alternative to expensive chemical cleanup methods for pharmaceutical pollution.

Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies

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Chronic pain affects millions of people and is often resistant to current treatments. This paper suggests that chronic pain emerges from interconnected biological, psychological, and social factors working together as a complex system. The authors propose that psychedelic-assisted therapies could help by breaking rigid thought and behavior patterns that maintain pain, allowing the brain and mind to reorganize in healthier ways, similar to how mindfulness meditation works but potentially more dramatically.

PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity

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This study is investigating whether psilocybin (an active compound in magic mushrooms) can help people with obsessive-compulsive disorder (OCD) by improving their mental flexibility and brain plasticity. Participants will receive two doses of psilocybin—a low test dose and a slightly higher therapeutic dose—four weeks apart, while receiving professional psychological support. Researchers will measure changes in cognitive abilities and brain activity to understand how psilocybin might help reduce OCD symptoms like intrusive thoughts and repetitive behaviors.

Research Topic: Medicinal