Medicinal – Page 50

Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression

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This research study is investigating how psilocybin, a compound from certain mushrooms, affects the brain in people with depression. The study involves 50 participants who will receive either psilocybin or a placebo, with their brain activity monitored using advanced imaging scans. Researchers will examine how psilocybin changes blood flow and network activity in brain regions involved in mood regulation, and whether these changes are linked to improvements in depression symptoms.

Psilocybin as Transformative Fast-Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

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Psilocybin, a compound from certain mushrooms, is being studied as a potential rapid-acting treatment for severe depression that doesn’t respond to standard antidepressants. Unlike conventional antidepressants that take weeks to work, psilocybin shows promise for producing mood improvements within days. The drug works by activating serotonin receptors in the brain and promoting the growth of new neural connections, though researchers are still working to fully understand how it achieves its antidepressant effects.

Comparative Analysis of Freeze-Dried Pleurotus ostreatus Mushroom Powders on Probiotic and Harmful Bacteria and Its Bioactive Compounds

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Researchers studied oyster mushrooms processed in different ways to understand their health benefits. The study found that cooked oyster mushroom powders can kill harmful bacteria and promote the growth of beneficial gut bacteria. These mushrooms also contain special particles called carbon nanodots that form during cooking and may enhance their health-promoting effects. The findings suggest oyster mushrooms could help maintain a healthy gut microbiota naturally.

A clinical protocol for group-based ketamine-assisted therapy in a community of practice: the Roots To Thrive model

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The Roots to Thrive ketamine-assisted therapy program is a 12-week group treatment that combines ketamine sessions with weekly group meetings, somatic practices, and emotional support. The program integrates both Western clinical approaches and Indigenous wisdom, treating depression, anxiety, and PTSD in groups of 20-40 participants. Over 750 people have participated with significant improvements in mental health symptoms and life functioning, demonstrating that this group-based approach is both safe and effective.

Antioxidant, Antibacterial and Dyeing Potential of Crude Pigment Extract of Gonatophragmium triuniae and Its Chemical Characterization

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Scientists discovered a rare orange-pigment-producing fungus called Gonatophragmium triuniae that has useful medicinal and practical applications. The fungus produces a natural pigment that can kill bacteria, protect against oxidative damage, and effectively dye cotton fabrics without toxic chemicals. The main active compound was identified as a phenoxazine derivative, suggesting potential uses in textiles, pharmaceuticals, and natural cosmetics as a safe alternative to synthetic pigments and antibiotics.

Further education in psychedelic-assisted therapy – experiences from Switzerland

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As psychedelic drugs show promise in treating serious mental health conditions like depression and PTSD, there is growing need to train therapists to safely administer these novel treatments. Switzerland’s leading medical association has developed a comprehensive three-year training program that combines classroom learning with hands-on practice to prepare doctors and psychologists. The program faces overwhelming demand, with far more people wanting to train than available spots, highlighting the urgent need for more specialized education programs as these treatments potentially become mainstream medications.

Molecular insights into the modulation of the 5HT 2A receptor by serotonin, psilocin, and the G protein subunit Gqα

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This study uses computer simulations to understand how psilocin (the active compound in magic mushrooms) and serotonin interact with a brain receptor called 5HT 2A R. The research shows that both molecules prefer to bind to a deeper part of the receptor rather than a shallower area, and that a protein called Gqα is essential for keeping the receptor in its active state. These findings could help scientists develop better medicines for depression and anxiety.

Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer

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This review explores how natural polysaccharides from mushrooms, seaweed, plants, and traditional herbs can fight gastric cancer. These compounds work by triggering cancer cell death, stopping tumor growth, and boosting the body’s immune system. Unlike conventional chemotherapy drugs that cause serious side effects, these natural polysaccharides offer a safer alternative that can work alongside existing treatments to improve patient survival.

Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report

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A 17-year-old girl became severely ill after eating a chocolate bar containing a medicinal mushroom product that was contaminated with muscimol, a toxic compound from poisonous mushrooms. She experienced confusion, uncontrollable muscle jerks, dilated pupils, and excessive drooling, requiring hospitalization and temporary breathing assistance. Though her symptoms resolved within 8 hours and she recovered fully, this case highlights the serious danger of unregulated mushroom supplements that can be contaminated with deadly toxins.

The Role of Plant Extracts in Enhancing Nutrition and Health for Dogs and Cats: Safety, Benefits, and Applications

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This review examines how plant-based supplements like tea extracts, curcumin, and quercetin can improve the health of pet dogs and cats. These natural compounds act as antioxidants and anti-inflammatory agents, supporting gut health, immune function, and overall wellness in companion animals. While generally safe when properly dosed, cats and dogs metabolize these compounds differently, requiring species-specific dosing strategies to maximize benefits and minimize risks.

Research Topic: Medicinal