Research Topic: Medicinal

Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites

Scientists have learned to use common baker’s yeast (S. cerevisiae) as a biological factory to produce valuable medicines and compounds that naturally come from fungi and mushrooms. By transferring the genetic instructions for making these compounds into yeast cells and improving them with genetic engineering, researchers can now produce therapeutically important substances like cancer-fighting drugs and antibiotics in large quantities. This approach is more practical and cost-effective than trying to extract these rare compounds directly from their native fungal sources or using other production methods.

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Implementing psychedelic-assisted therapy: History and characteristics of the Swiss limited medical use program

Switzerland operates a unique program allowing controlled use of psychedelics (LSD, psilocybin) and MDMA to help patients with serious mental health conditions that haven’t responded to standard treatments. Since 2014, about 100 doctors have treated 700+ patients with these substances as part of therapy sessions. The program requires careful patient screening, informed consent, and outcome reporting, with patients typically receiving 2-4 treatments over 12 months. Most patients showed significant improvement in their conditions, though some experienced side effects like nausea or headaches.

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Anti-Inflammatory Effects of Solanum tuberosum L. Polysaccharide and Its Limited Gene Expression Profile

Researchers studied a natural compound from potatoes called STP that reduces inflammation in the body. Using laboratory cells and animal models, they found that STP works similarly to the common pain reliever ibuprofen by reducing inflammatory chemicals and activating the body’s protective defense systems. This discovery suggests that potato-based polysaccharides could be developed into new treatments for inflammatory diseases and conditions related to oxidative stress.

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Why psychedelic-assisted therapy studies in eating disorders risk missing the mark on outcomes: a phenomenological psychopathology perspective

This scientific commentary examines how research on psychedelic-assisted therapy for eating disorders may be missing important aspects of how people actually experience the treatment. The authors argue that current study methods rely too heavily on questionnaires that don’t capture the full depth of what people experience during psychedelic sessions. They propose using phenomenological approaches—methods that deeply explore lived experience—to better understand which aspects of the psychedelic experience actually lead to recovery from eating disorders.

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Current situation regarding psychedelics and magic mushroom in Korea

This article reviews the current status of psychedelic mushrooms and their potential medical uses in Korea. Several wild mushroom species containing psilocybin have been identified in Korea and can cause hallucinations and other nervous system effects lasting a few hours. While psychedelics show promise for treating depression and anxiety, Korea currently classifies them as controlled substances, and only approved clinical trials can be conducted with government permission.

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Experimental research on fungal inhibition using dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase

Researchers developed a new patch treatment for nail fungus using tiny dissolving needles that deliver antifungal medication directly into the skin near infected nails. The patch combines two active ingredients that work together to kill fungus and break down protective biofilm layers that make fungal infections hard to treat. Testing showed the patch was safe, effective, and delivered much more medication to the infected area compared to traditional creams or pills.

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Harnessing the Nutritional Value, Therapeutic Applications, and Environmental Impact of Mushrooms

Mushrooms are nutritional powerhouses packed with proteins, vitamins, minerals, and special compounds that fight disease. They can help prevent and manage serious conditions like cancer, heart disease, and diabetes while supporting overall health and immunity. Beyond the kitchen, mushrooms are being developed into medicines and cosmetic products. Growing and using mushrooms also helps the environment by creating sustainable alternatives to traditional medicines and animal feeds.

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Comparative Analysis of Main Agronomic Traits of Different Pleurotus giganteus Germplasm Resources

Scientists studied 15 different varieties of giant oyster mushrooms to understand their growth characteristics and quality traits. They tested how fast the mushroom threads grow at different temperatures, measured the size and weight of the mushrooms produced, and calculated how efficiently each variety converts growing material into edible mushrooms. Strain No. 9 performed best with the largest yields and highest quality mushrooms, while different strains showed distinct characteristics that could be used to develop superior commercial varieties.

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Single-dose psilocybin alters resting state functional networks in patients with body dysmorphic disorder

Researchers gave eight patients with body dysmorphic disorder (an excessive preoccupation with appearance flaws) a single dose of psilocybin and measured their brain activity before and after treatment. They found that psilocybin increased communication between key brain regions involved in decision-making and attention control. Patients whose brains showed these changes experienced significant symptom improvement within a week, suggesting psilocybin may help by enhancing mental flexibility and emotional regulation in BDD.

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