Medicinal – Page 19

Synergy of de-walled Ganoderma Lucidum spore powder (GLSP) on targeted therapy in advanced non-squamous non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutant: protocol for a randomized, double-blind, placebo-controlled study

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This study tests whether Ganoderma lucidum spore powder, a traditional Chinese medicine supplement, can help reduce fatigue in lung cancer patients taking the drug Osimertinib. Fatigue is a major side effect that affects most patients on this medication. The 140-patient trial compares patients receiving the supplement plus Osimertinib with those receiving a placebo plus Osimertinib, measuring fatigue levels and quality of life over 8 weeks.

Psychedelic-Assisted Therapy: Potential Benefits and Challenges in Mental Health Treatment

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This review examines how psychedelic substances like psilocybin and MDMA, when combined with professional psychotherapy, show promise in treating difficult-to-treat mental health conditions including depression, PTSD, and anxiety. While early research suggests these substances could help in cases where conventional treatments have failed, the evidence is still preliminary and limited by small study sizes. Psychedelics appear to work by changing how the brain processes information and memories, though much more rigorous research is needed before they can be considered standard treatments.

Evaluation of Lipid Changes During the Drying Process of Cordyceps sinensis by Ultra Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS)-Based Lipidomics Technique

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This study examines how different drying methods affect the lipid content of Cordyceps sinensis, a valuable medicinal mushroom. Researchers compared three drying techniques—freeze-drying, oven-drying, and air-drying—and found that freeze-drying best preserves the mushroom’s beneficial lipids, while oven-drying causes significant degradation. The findings provide practical guidance for mushroom producers on selecting optimal drying methods to maintain the medicinal quality and nutritional value of this prized fungus.

Acute Kidney Failure and Myocarditis Triggered by Magic Mushroom Toxicity in a Patient With Prior Cocaine Exposure

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A middle-aged man who used magic mushrooms along with alcohol and LSD developed severe kidney failure and heart inflammation. He had previously used cocaine, which made his condition worse by promoting blood clots throughout his body. Despite dialysis treatment, his kidneys stopped working, he developed heart problems and blood clots in major blood vessels, and he unfortunately passed away. This case highlights how dangerous it can be to mix magic mushrooms with other drugs, especially for people with a history of cocaine use.

Production of Myco-Nanomaterial Products from Pleurotus ostreatus (Agaricomycetes) Mushroom via Pyrolysis

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Scientists have discovered a new way to create tiny fluorescent particles called carbon nanodots from oyster mushrooms using heat treatment. These particles glow under certain light conditions and show promising ability to fight bacteria like E. coli. The process is environmentally friendly, uses waste mushroom material, and could lead to new ways to treat infections and reduce dependence on antibiotics.

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii

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Researchers isolated tiny particles called extracellular vesicles (EVs) from a medicinal mushroom called king oyster mushroom (Pleurotus eryngii). These EVs act like natural delivery packages containing beneficial compounds like antioxidants and anti-inflammatory molecules. The study found that EVs from mushroom mycelium (the root-like part) were purer and more potent than those from the mushroom cap, with strong abilities to neutralize harmful free radicals in the body.

Dr. Muhammed Majeed: Father of Indian nutraceuticals industry- a life profile

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Dr. Muhammed Majeed transformed the nutraceutical industry by using modern science to validate and improve traditional Ayurvedic herbs. He founded Sabinsa Corporation and created patented, scientifically-proven products like turmeric extract (Curcumin C3 Complex®) and black pepper extract (BioPerine®) that are now used worldwide. Beyond business, he pioneered sustainable farming practices for medicinal plants across India and Africa, helping thousands of farmers improve their livelihoods while ensuring quality ingredients.

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial

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This study tested whether Ganoderma lucidum, a medicinal mushroom used in traditional Asian medicine, could treat denture stomatitis as effectively as the standard treatment clotrimazole. Both treatments reduced pain and improved symptoms equally well over two weeks. The results suggest that Ganoderma lucidum could be a useful alternative for patients who don’t respond well to standard antifungal drugs.

Dietary live microbe intake and its association with Parkinson’s disease in American adults: an NHANES analysis (1999–2018)

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This study found that eating more foods rich in live microbes—like fermented products (yogurt, kimchi) and fresh fruits and vegetables—is associated with lower rates of Parkinson’s disease in American adults. The protective effect was strongest in people without obesity. The live microbes appear to work by maintaining a healthy gut environment, reducing inflammation, and protecting nerve cells from damage. This suggests that regular consumption of microbe-rich foods from nature might be a simple, inexpensive way to help prevent or slow Parkinson’s disease.

Catalyst for change: Psilocybin’s antidepressant mechanisms—A systematic review

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This research review examines how psilocybin, a compound from certain mushrooms, may help treat depression by creating changes in both brain function and psychological experience. Within supportive therapeutic settings, psilocybin appears to increase cognitive flexibility, help people better process emotions, and restore a sense of connection to themselves, others, and the world. The antidepressant benefits seem to work through a combination of direct brain changes and psychotherapeutic factors, rather than through pure pharmacological action alone.

Research Topic: Medicinal