Medicinal – Page 156

Retrospective Analysis on the Efficacy and Adverse Effects of Antifungal Prophylaxis in Patients with Peritoneal Dialysis-Associated Peritonitis

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This study examined whether giving antifungal medications to peritoneal dialysis patients with infections could prevent fungal peritonitis. The researchers found that patients receiving antifungal prophylaxis actually had higher rates of secondary fungal infections compared to those without it. Additionally, fluconazole treatment was associated with dangerous changes in heart electrical activity, suggesting potential cardiac risks.

Whole genome sequencing and annotations of Trametes sanguinea ZHSJ

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Scientists sequenced the complete genome of Trametes sanguinea, a medicinal mushroom used in traditional Chinese medicine, grown in China. The mushroom’s tissue contains beneficial compounds that may help fight tumors, protect the heart, boost immunity, and heal diabetic wounds. By mapping out all 10,886 genes in this fungus, researchers now have detailed blueprints to understand how it produces these healing compounds and potentially grow them industrially for medical use.

The transcription factor RttA contributes to sterol regulation and azole resistance in Aspergillus fumigatus

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Researchers corrected the mislabeled rttA gene in the dangerous fungus Aspergillus fumigatus and discovered it acts as a master control switch for sterol production and antifungal drug resistance. When this gene is active, it helps fungi survive azole medications by boosting production of ergosterol, a critical component of fungal cell membranes. This discovery reveals how fungi develop resistance to our frontline antifungal treatments and suggests new ways to combat these life-threatening infections.

Multiomics Provides a New Understanding of the Effect of Temperature Change on the Fermentation Quality of Ophiocordyceps sinensis

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This research studied how temperature affects the growth and quality of Ophiocordyceps sinensis, a valuable medicinal fungus. Scientists found that the fungus grows best between 18-23°C, and that temperatures above 28°C damage the fungus by triggering cell death processes. The study identified which genes and metabolites are affected by temperature changes, helping optimize large-scale production of this medicinal fungus.

Kojic Acid Showed Consistent Inhibitory Activity on Tyrosinase from Mushroom and in Cultured B16F10 Cells Compared with Arbutins

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This study compared four skin-whitening compounds to find the best one for use as a testing standard in laboratories. Kojic acid was found to be the most reliable choice because it effectively blocks the enzyme tyrosinase, which produces skin pigment, without damaging cells. The researchers tested these compounds both in test tubes and in actual melanoma cells to understand how they work differently.

A Chromosome-Scale Genome of Trametes versicolor and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis

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Scientists created a detailed map of the Trametes versicolor mushroom’s genetic code using advanced sequencing technologies. This medicinal mushroom is known for cancer-fighting and immune-boosting properties. The research discovered that light exposure increases the production of beneficial compounds called triterpenes, which may explain how this mushroom’s medicinal qualities work and could help scientists grow it more effectively.

Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders

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Autism spectrum disorder affects social abilities in millions of people, but the underlying causes remain poorly understood. This research discovered that in the brains of people with autism, certain cellular processes that control energy and signaling become overactive, particularly in the region controlling social behavior. The good news is that the researchers found a drug-like compound called XAV939 can restore normal function by blocking the abnormal interaction between two key proteins, potentially offering a new treatment approach.

Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

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A natural compound called chitoglucan extracted from enoki mushrooms (Flammulina velutipes) was found to reduce weight gain and body fat in mice fed a high-fat diet. The treatment worked by lowering levels of hormones called leptin and resistin that are elevated in obesity. This suggests that chitoglucan from enoki mushrooms could potentially help treat obesity and related metabolic disorders in humans.

Prevalence of Tinea pedis in military personnel: a systematic review and meta-analysis

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Athlete’s foot is a common fungal infection affecting military personnel at rates around 17% globally. Military environments create perfect conditions for this infection through close living quarters, humidity from sweat and boots, and shared facilities. The study found that regions with hot, humid climates have higher infection rates, and proper diagnosis using both microscopy and culture tests is important for accurate detection. Improved hygiene, better-designed footwear, and access to antifungal treatments can significantly reduce infection rates in military settings.

Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris

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Researchers tested an edible mushroom called Cordyceps militaris to see if it could fight SARS-CoV-2, the virus that causes COVID-19. Using computer modeling and laboratory experiments, they found that a compound in the mushroom called cordycepin strongly attached to the virus’s spike protein and reduced viral numbers by about 50% in cell cultures. The study supports traditional uses of this mushroom and suggests it could be helpful in managing COVID-19 as the disease becomes endemic.

Research Topic: Medicinal