Research Topic: lipid metabolism

Expression pattern, subcellular localization of Aspergillus oryzae ergosterol synthases, and their effects on ergosterol and fatty acid metabolism

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Researchers studied how Aspergillus oryzae fungi make ergosterol, a key ingredient in fungal cell membranes. They found that this process is much more complex in this mold than in baker’s yeast, with 49 genes involved. By selectively increasing expression of specific genes, they were able to boost ergosterol production by up to 2.3 times, which could have applications in producing fungal-derived medicines and improving fermented foods.

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Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

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This research examines how immune cells (macrophages) respond differently to active versus dormant forms of a dangerous fungus called Cryptococcus neoformans. The dormant form causes the immune cells to accumulate fatty acids differently than the active fungus, which may help the fungus establish long-term infections. Understanding these differences could lead to better treatments for cryptococcal infections, which are particularly dangerous for immunocompromised individuals.

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