Invasive fungal infections – Page 6

Gastrointestinal and Intra-Abdominal Mucormycosis in Non-Haematological Patients—A Comprehensive Review

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This review examines a serious but rare fungal infection called mucormycosis that affects the stomach and intestines. The infection most commonly occurs in patients with diabetes, those who have received organ transplants, or those in intensive care units. Diagnosis can be difficult because symptoms are non-specific, but prompt treatment with antifungal medications and surgery when possible significantly improves survival rates. Early recognition and rapid diagnosis are critical for patients to have the best outcomes.

Addressing Critical Fungal Pathogens Under a One Health Perspective: Key Insights from the Portuguese Association of Medical Mycology

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This comprehensive study by Portugal’s mycology experts examines four dangerous fungi that cause severe infections: Aspergillus fumigatus, Candida auris, Candida albicans, and Cryptococcus neoformans. The research shows that Portugal’s hospitals have varying capabilities to diagnose and treat these infections, with some laboratories well-equipped and others lacking advanced diagnostic tools. The study found concerning increases in antifungal resistance and highlights that these fungi live in hospitals, water systems, soil, and even animals, emphasizing the need for integrated approaches connecting human, animal, and environmental health to better protect public health.

Incidence And Risk Factors for Invasive Fungal Infections in Pre-Transplant and Transplant-Ineligible Multiple Myeloma in the U.S.: A Claims Analysis (2017-2021)

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This study examined fungal infections in patients with multiple myeloma who were not eligible for or preparing for stem cell transplants. Researchers found that 6% of these patients developed invasive fungal infections, with yeast infections being the most common type. The risk of these infections was significantly higher in patients taking dexamethasone (a steroid) or those with low white blood cell counts and those receiving multiple cancer therapies.

Pan-Indian Clinical Registry of Invasive Fungal Infections Among Patients in the Intensive Care Unit: Protocol for a Multicentric Prospective Study

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Fungal infections are a serious hidden threat in hospital intensive care units, particularly for patients with weakened immune systems. This study establishes India’s first comprehensive database system to track fungal infections across 8 major medical centers nationwide. By collecting detailed information about these infections and how they respond to treatments, the research aims to help doctors diagnose and treat fungal infections faster and more effectively. The findings will guide better clinical practices and public health policies to combat these often-neglected but deadly infections.

Geotrichosis Due to Magnusiomyces capitatus: A Severe Emerging Invasive Fungal Disease

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A 71-year-old cancer patient receiving chemotherapy developed a severe blood infection caused by a rare fungus called Magnusiomyces capitatus. This emerging fungal infection caused septic shock and multiple organ failure despite treatment with antifungal medications. The case highlights how these rare fungi can be deadly in patients with weakened immune systems and emphasizes the importance of quick, accurate identification using advanced laboratory techniques to guide treatment decisions.

Efficacy of SCY-247, a Second-generation Triterpenoid Antifungal, in Three Murine Models of Invasive Fungal Infections

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Researchers tested a new antifungal drug called SCY-247 in mice to treat serious fungal infections. The drug was given orally and showed strong effectiveness against common fungal infections caused by Candida and Rhizopus species, including strains resistant to current treatments. Higher doses of the drug produced better results, and the drug effectively concentrated in the organs most affected by fungal infections.

Invasive Cutaneous Mucormycosis in a Patient With Chronic Lymphocytic Leukemia on Obinutuzumab, Idelalisib, and Bruton Tyrosine Kinase Degrader: A Case Report

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A 74-year-old man with leukemia developed a serious fungal infection (mucormycosis) on his ankle while taking cancer-fighting drugs. The infection was diagnosed through tissue biopsy examination rather than standard culture tests. Treatment required both powerful antifungal medications and surgical removal of the infected leg below the knee. The patient recovered successfully after this aggressive treatment approach.

Cutaneous Purpureocillium lilacinum and Fusarium coinfection in a heart transplant recipient

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A heart transplant patient developed multiple nodular skin lesions caused by two rare types of mold fungi growing together. Doctors diagnosed the infection through skin biopsy and identified the fungi using laboratory techniques. The patient was successfully treated with the antifungal medication voriconazole for six months and made a full recovery without relapse.

Research Topic: Invasive fungal infections