Inflammation – Page 2

Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain

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Researchers found that psilocybin, the active ingredient in magic mushrooms, significantly reduced chronic pain in mice through activation of specific serotonin receptors. The effects lasted for up to two weeks after a single dose, suggesting lasting changes in how the nervous system processes pain. This study suggests psilocybin could be a promising new treatment for chronic pain conditions like neuropathy and inflammation.

The Immune Mind: Linking Dietary Patterns, Microbiota, and Psychological Health

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This review shows that what we eat significantly affects our mental health through our gut bacteria and immune system. Mediterranean-style diets rich in vegetables, whole grains, and healthy fats can help reduce depression and anxiety symptoms. Conversely, ultra-processed foods with added sugars and artificial ingredients increase the risk of mental health problems. Specific probiotic supplements may also provide modest benefits for mood by promoting beneficial gut bacteria.

Plant and Fungal Polysaccharides in Periodontitis Treatment: Diverse Mechanisms and Therapeutic Roles

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Periodontitis is a serious gum disease that causes tooth loss and affects overall health. This review examines how polysaccharides (complex carbohydrates) from plants and fungi can help treat periodontitis by reducing inflammation, fighting bacteria, and helping gum tissue repair. These natural compounds work through multiple biological pathways to improve oral health outcomes while avoiding the side effects and resistance problems associated with conventional drugs.

The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

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Researchers tested a natural mixture of five medicinal mushrooms combined with cannabidiol (CBD) on immune cells exposed to bacterial endotoxins. The formulation effectively reduced inflammatory response markers without harming the cells. These findings suggest the mixture could potentially be used to treat inflammatory conditions like asthma and arthritis, though more research is needed.

The Therapeutic Effect and Mechanism of Traditional Chinese Medicine in Type 2 Diabetes Mellitus and Its Complications

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Traditional Chinese Medicine uses various herbs and plant compounds to treat Type 2 diabetes by improving how the body controls blood sugar and protects the pancreas. Many common TCM herbs like ginseng, rehmannia, and coptis work through natural mechanisms that reduce inflammation, protect cells from damage, and improve how the body uses insulin. Research shows TCM may also help prevent or reduce diabetes-related complications affecting the eyes, kidneys, and nerves. These herbal treatments offer potential benefits with fewer side effects compared to conventional medications.

Inonotus hispidus Protects against Hyperlipidemia by Inhibiting Oxidative Stress and Inflammation through Nrf2/NF-κB Signaling in High Fat Diet Fed Mice

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Inonotus hispidus is an edible mushroom that may help treat obesity and high cholesterol by reducing fat levels and inflammation in the body. In mice fed a high-fat diet, the mushroom improved cholesterol profiles, reduced liver damage, and promoted beneficial gut bacteria. The beneficial effects appear to work through activating the body’s natural antioxidant defenses and reducing inflammation-causing proteins.

Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress

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Researchers studied a natural supplement made from reishi mushroom and black locust flower to treat kidney disease. In laboratory and animal tests, this supplement reduced kidney damage by lowering harmful molecules called free radicals and controlling inflammation. The supplement worked by blocking specific pathways that cause kidney inflammation and scarring, suggesting it could be a helpful natural treatment for people with chronic kidney disease.

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

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ELAV/Hu proteins are molecular machines that control how cells read and use genetic instructions. Found mostly in the brain and nervous system, these proteins help manage which genes get turned on or off, which is crucial for proper brain development and function. When these proteins go wrong, they can contribute to serious diseases like Alzheimer’s, Parkinson’s, cancer, and autism, making them promising targets for new treatments.

Recent Discoveries on Marine Organism Immunomodulatory Activities

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Scientists are discovering that creatures from the ocean produce powerful substances that can help our immune system fight diseases like cancer and inflammation. These marine organisms—from tiny algae to sponges to fish—create natural compounds that can either boost or calm down our immune response depending on what we need. Several of these ocean-derived medicines are already approved for treating serious diseases, and many more are being tested in clinical trials. The ocean covers 70% of our planet and most of it remains unexplored, suggesting there are many more beneficial compounds waiting to be discovered.

Edible Mushrooms and Beta-Glucans: Impact on Human Health

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Mushrooms contain compounds called β-glucans that can help boost your immune system and reduce inflammation. These compounds show promise in cancer treatment when combined with conventional therapies and may help fight infections. While mushrooms have long been used in traditional medicine, modern research is confirming their health benefits and understanding how they work in the body.

Research Topic: Inflammation