immune response – mycolab.ai

Gut Microbiome and Immune System Crosstalk in Chronic Inflammatory Diseases: A Narrative Review of Mechanisms and Therapeutic Opportunities

mycolabadmin

Your gut contains trillions of bacteria that play a crucial role in keeping your immune system balanced. When this bacterial community becomes imbalanced (dysbiosis), it can lead to chronic inflammatory diseases like arthritis, inflammatory bowel disease, psoriasis, and lupus. Recent research shows that restoring a healthy gut microbiota through diet, probiotics, prebiotics, or fecal transplants may help treat these conditions by reducing inflammation and strengthening the gut barrier.

Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial

mycolabadmin

A study tested whether a supplement made from Reishi mushroom could boost immune system function in healthy adults. Over 84 days, people taking the Reishi β-glucan supplement showed significant improvements in immune cells and antibodies compared to those taking a placebo. The supplement was safe and well-tolerated with no negative side effects, suggesting it may help strengthen the body’s natural defenses against infections.

Individual and Combined Effect of Zinc-L-Selenomethionine Complex with Mannan-Oligosaccharide on Growth Performance, Carcass Characteristics, Gut Development and Immune Response in Broilers

mycolabadmin

This study tested whether combining organic selenium and a prebiotic from yeast could improve broiler chicken health without using antibiotics. The researchers fed different groups of chickens either selenium alone, the prebiotic alone, or combinations of both at different levels over 35 days. They found that the combination of higher selenium levels with the prebiotic worked best for improving meat quality, immune system strength and gut health, making it a promising natural alternative to growth-promoting antibiotics in chicken farming.

Recent Discoveries on Marine Organism Immunomodulatory Activities

mycolabadmin

Scientists are discovering that creatures from the ocean produce powerful substances that can help our immune system fight diseases like cancer and inflammation. These marine organisms—from tiny algae to sponges to fish—create natural compounds that can either boost or calm down our immune response depending on what we need. Several of these ocean-derived medicines are already approved for treating serious diseases, and many more are being tested in clinical trials. The ocean covers 70% of our planet and most of it remains unexplored, suggesting there are many more beneficial compounds waiting to be discovered.

Recent Knowledge in the Application of Saccharomyces cerevisiae in Aquaculture: A Bibliometric and Narrative Review

mycolabadmin

This comprehensive review examines how baker’s yeast (Saccharomyces cerevisiae) is being used as a probiotic supplement in fish farming and aquaculture. The research shows that adding this yeast to fish feed improves growth rates, helps fish fight off diseases, and creates healthier gut bacteria in aquatic animals. Scientists worldwide are increasingly studying this natural alternative to antibiotics, with studies demonstrating benefits across various fish species including tilapia, trout, and catfish, making it an important tool for sustainable and healthier aquaculture practices.

Pathogenic characterization of Phialophora submersa, a new black yeast isolated from freshwater sediments in Spain

mycolabadmin

Scientists discovered a new black yeast fungus called Phialophora submersa in Spanish river sediments and tested whether it could infect humans. Using laboratory macrophage (immune cell) models, they found that this environmental fungus exhibits pathogenic potential similar to known disease-causing Phialophora species, though at intermediate levels. The fungus showed resistance to some antifungal drugs and displayed strain-dependent ability to survive various stress conditions. This research suggests that environmental fungal species may pose unexpected health risks despite not being able to grow at normal human body temperature.

One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia

mycolabadmin

This editorial discusses how bacteria, viruses, and fungi interact in the lungs during severe pneumonia from COVID-19 or influenza. When mechanically ventilated patients with COVID-19 had bacterial infections detected, their immune systems released more inflammatory chemicals. However, the same pattern was not observed in influenza patients. Understanding how all these microorganisms work together may help doctors better treat these serious lung infections.

Fluconazole worsened lung inflammation, partly through lung microbiome dysbiosis in mice with ovalbumin-induced asthma

mycolabadmin

Fluconazole is an antifungal medication that works well for treating asthma caused by fungal infections, but may actually worsen asthma from other causes. In mice with allergic asthma, fluconazole killed beneficial bacteria and promoted the growth of harmful bacteria that increased inflammation. This study suggests that fluconazole should only be used for fungal-related asthma and careful monitoring is needed if used in patients with regular asthma.

Research Topic: immune response