Research Topic: gut microbiota

Effects of Natural Polysaccharides on the Gut Microbiota Related to Human Metabolic Health

Natural plant and organism sugars called polysaccharides can improve your gut health by feeding beneficial bacteria and strengthening your intestinal barrier. These compounds help prevent diseases like obesity, diabetes, and inflammatory bowel disease by changing the types of bacteria in your gut and producing helpful substances. Polysaccharides come from common foods like mushrooms, seaweed, berries, and vegetables, making them potential natural treatments for various health conditions.

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Potential relationship between gut microbiota and animal diarrhea: a systematic review

This review explains how the trillions of microorganisms living in animal intestines are crucial for health and digestion. When these microbial communities become imbalanced, animals develop diarrhea, which is a major problem in farming causing economic losses and animal suffering. The review shows that adding beneficial bacteria (probiotics) and their food sources (prebiotics) to animal diets can restore balance and prevent diarrhea, offering practical solutions to reduce the need for antibiotics.

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Effects of Short-Chain Fatty Acid Combinations Relevant to the Healthy and Dysbiotic Gut upon Candida albicans

Short-chain fatty acids produced by healthy gut bacteria appear to slow the growth and reduce the invasive characteristics of Candida albicans, a fungus that normally lives harmlessly in the gut but can cause infections when the microbiota is disrupted by antibiotics. This study tested whether healthy gut SCFA levels inhibit Candida more effectively than dysbiotic levels and found that the healthy SCFA mix was somewhat more effective at preventing fungal hyphal formation, which is important for tissue invasion. However, different Candida strains responded differently to the SCFAs, suggesting that individual variation affects how protective these bacterial metabolites can be.

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Mushroom stem-based diets elicit region-specific shifts in rainbow trout gut microbiota

Researchers fed rainbow trout different diets containing mushroom stem waste from grocery stores for six weeks and studied how the mushroom ingredients affected the fish’s gut bacteria. They found that mushroom diets promoted beneficial bacteria in different parts of the fish’s intestine without harming the fish. This research shows that mushroom waste can be recycled into healthy fish feed while supporting the fish’s digestive health and supporting a more circular food system.

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Cross-cohort microbiome-wide study reveals consistent alterations in the gut bacteriome, but not the gut mycobiome, in patients with hypertension

Researchers analyzed gut bacteria and fungi in hypertensive patients compared to healthy people across two regions in China. They found that hypertensive patients have significant changes in their gut bacteria, particularly an overgrowth of harmful species like Clostridium and a decrease in beneficial bacteria. Interestingly, fungi in the gut showed minimal differences. These bacterial changes could potentially be used as early warning signs for hypertension and might become targets for new treatments.

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Impact of Phellinus gilvus mycelia on growth, immunity and fecal microbiota in weaned piglets

Researchers tested whether a medicinal mushroom called Phellinus gilvus could replace antibiotics in pig feed as a growth promoter. Over 28 days, piglets fed mushroom-supplemented diets grew as well as those given antibiotics while showing even better immune system activation. Unlike antibiotics that drastically changed the gut bacteria composition, the mushroom only slightly modified it while still reducing harmful E. coli bacteria. This suggests the mushroom could be a safer alternative to antibiotics in pig farming.

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Novel Approaches in Glucose and Lipid Metabolism Disorder Therapy: Targeting the Gut Microbiota–Bile Acid Axis

Your gut bacteria play a key role in how your body manages blood sugar and fats, working through molecules called bile acids. Researchers have discovered that certain foods, supplements, and herbs can improve this gut bacteria-bile acid interaction to help prevent or treat diabetes and obesity. This review explains how these natural interventions work and suggests promising new ways to treat metabolic diseases by harnessing your gut health.

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Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers

Researchers studied how a medicinal mushroom extract called Phellinus linteus polysaccharides could help broiler chickens recover from immune stress caused by bacterial toxins. The supplement improved the chickens’ growth, reduced harmful inflammatory responses, and promoted beneficial gut bacteria while reducing harmful ones. The treatment strengthened the intestinal barrier and restored the chickens’ natural antioxidant defenses. This suggests the mushroom supplement could be a natural alternative to antibiotics for improving poultry health on farms.

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The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy

Sepsis can cause brain dysfunction called sepsis-associated encephalopathy, leading to memory problems and confusion in about one-third to two-thirds of sepsis patients. The bacteria in your gut communicate with your brain through multiple pathways, and when sepsis disrupts this communication, it causes harmful inflammation in the brain. Treatments like probiotics and transplanting healthy gut bacteria from donors show promise in animal studies and early human trials for improving memory and cognitive function after sepsis.

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