Scientists have developed a new technique for editing genes in a dangerous fungal pathogen called Aspergillus fumigatus. Instead of permanently attaching antibiotic resistance markers to the target genes (which can interfere with normal gene function), they use a clever strategy of introducing two different DNA pieces simultaneously. One piece makes the desired gene edit while the second introduces a resistance marker to a completely different location in the genome. This approach is simple, inexpensive, and works about 11% of the time, making it practical for identifying successfully edited strains.