Research Topic: fungal secondary metabolism

Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene

Scientists discovered that a fungal enzyme from the black poplar mushroom (Cyclocybe aegerita) can produce two different types of beneficial compounds called terpenes. Using a baker’s yeast relative as a host organism, they found that the enzyme makes both a known sesquiterpene and an entirely new diterpene compound they named cyclocybene. This discovery shows that fungi can be better factories for producing these valuable compounds than bacteria previously used, opening doors for developing new medicines, fragrances, and biofuels.

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Unprecedented Mushroom Polyketide Synthases Produce the Universal Anthraquinone Precursor

Scientists discovered that mushrooms in the Cortinarius genus use unique enzymes called polyketide synthases to produce chemical building blocks that become anthraquinone compounds. These mushroom enzymes work differently from similar enzymes found in molds and plants, showing that nature independently invented multiple ways to make the same important molecules. This finding reveals how different organisms evolved similar chemical-making abilities through completely different evolutionary paths, and suggests this principle applies to many other mushroom species as well.

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Glucose-6-Phosphate Dehydrogenase Modulates Shiraia Hypocrellin A Biosynthesis Through ROS/NO Signaling in Response to Bamboo Polysaccharide Elicitation

Researchers discovered that a naturally derived compound from bamboo boosts the production of hypocrellin A, a promising cancer-fighting and antimicrobial agent made by a special fungus. By studying a key enzyme called G6PDH, they found that it acts as a molecular switch controlling hypocrellin production when the fungus senses bamboo components. This discovery enables cost-effective large-scale production of this powerful medicine through simple fermentation, potentially making novel cancer treatments and antibiotics more accessible.

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