Research Topic: Fermentation optimization

Development of Biphasic Culture System for an Entomopathogenic Fungus Beauveria bassiana PfBb Strain and Its Virulence on a Defoliating Moth Phauda flammans (Walker)

Researchers developed an efficient two-stage fermentation process to mass-produce Beauveria bassiana PfBb, a fungus that kills defoliating moths damaging Ficus trees. The first stage grows the fungus in liquid to produce active spores, which are then transferred to solid substrates to produce hardy, long-lasting conidia. The optimized process produces high quantities of effective fungal spores that can be stored at refrigerator temperature for over a year while maintaining their pest-killing ability.

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Engineered biosynthesis and characterization of disaccharide-pimaricin

Scientists successfully created a genetically engineered bacterium that produces a safer version of an antifungal drug called pimaricin. The new version, called disaccharide-pimaricin, dissolves much better in water and causes significantly less damage to human blood cells, making it a much safer option for treating fungal infections. Although it’s slightly less effective at killing fungi, the improvement in safety and solubility makes it a promising candidate for treating eye infections and other fungal diseases.

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