Research Topic: drug susceptibility

The emerging fungal pathogen Cryptococcus gattii: Epidemiology, pathogenesis, immunomodulatory attributes, and drug susceptibility

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Cryptococcus gattii is a dangerous fungal infection that can affect even healthy people, unlike most fungal infections that target those with weak immune systems. The fungus uses clever tricks to hide from the immune system, including creating protective capsules and producing melanin. Current antifungal drugs like fluconazole are becoming less effective as the fungus develops resistance, making this an urgent public health concern that requires better treatments and early detection.

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Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi

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Scientists have proposed clear definitions and testing methods for two drug-resistance phenomena in fungi that cause infections. Unlike typical drug resistance, tolerance and persistence allow fungi to survive antifungal medications but in different ways: tolerance affects most spores while persistence affects only a small fraction. By standardizing how these phenomena are tested using fungal spores and measuring how quickly drugs kill them, researchers can better understand treatment failures and develop better therapies.

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Itraconazole resistance in Madurella fahalii linked to a distinct homolog of the gene encoding cytochrome P450 14-α sterol demethylase (CYP51)

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A fungal infection called mycetoma caused by Madurella fahalii doesn’t respond to a common antifungal drug called itraconazole. Researchers discovered that this fungus has an extra gene that produces a protein that resists the drug, which isn’t found in a similar fungus that remains susceptible. This finding could help develop better treatments for mycetoma patients in the future.

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