Research Topic: drug interactions

The in vitro activity of iron chelator deferiprone against Candida (Candidozyma) auris in combination with antifungal agents

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Researchers studied how an iron-chelating medication called deferiprone could improve the effectiveness of antifungal drugs against Candida auris, a dangerous drug-resistant fungus. They tested deferiprone combined with several common antifungal medications on different strains of the fungus from around the world. They found that deferiprone worked best when combined with echinocandin drugs, especially against certain regional variants of the fungus, potentially offering a new therapeutic approach for these difficult-to-treat infections.

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Deep Fungal Infection of the Skin with Two Rare Fungi in a Dog Being Treated with Immunosuppressant Therapy: A Case Report

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An 8-year-old dog receiving long-term immunosuppressive medication for brain inflammation developed rare fungal skin infections caused by two unusual fungi not previously reported together in veterinary medicine. Diagnosis required multiple tests including tissue samples, staining techniques, and genetic testing. Despite treatment with antifungal medications and careful adjustment of immunosuppressive drugs, the infections did not improve, highlighting the difficult balance between fighting infections and controlling the underlying immune disease.

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