drug combinations – mycolab.ai

Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates

mycolabadmin

Scientists tested combinations of common antifungal medications with special inhibitor drugs that target fungal stress-response systems. When combined, these drugs worked better together against dangerous mold infections like Aspergillus and Rhizopus, especially those that are resistant to standard treatments. The combinations rarely caused harmful interactions and often enhanced the antifungal effects, suggesting this approach could improve treatment of serious mold infections.

Investigation of the antifungal activity of panobinostat, tamoxifen, and miltefosine alone and in combination with some conventional antifungal drugs against fluconazole-resistant Candida species

mycolabadmin

Researchers tested whether three cancer drugs (panobinostat, tamoxifen, and miltefosine) could enhance the effectiveness of common antifungal medications against drug-resistant yeast infections. When combined with antifungals, some of these cancer drugs showed promise in killing resistant Candida species, though the effectiveness varied depending on which type of yeast was being treated. These findings suggest that combination therapies using already-approved drugs could help treat difficult fungal infections in cancer patients.

Research Topic: drug combinations

Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates

Investigation of the antifungal activity of panobinostat, tamoxifen, and miltefosine alone and in combination with some conventional antifungal drugs against fluconazole-resistant Candida species