Research Topic: diabetes complications

Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study

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Researchers studied a compound from the Flammulina velutipes mushroom (enoki mushroom) to see if it could help protect gum tissue in people with both diabetes and gum disease. Using human gum cell samples exposed to disease-simulating conditions, they found that the mushroom polysaccharides reduced cell damage, decreased inflammation, and prevented a harmful type of cell death called pyroptosis. The results suggest this mushroom compound could potentially be used as a supplementary treatment for people with diabetes-related gum disease.

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Impact of glycemic control on coccidioidomycosis outcomes in patients with underlying diabetes mellitus in central California

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This study examined how blood sugar control affects outcomes in patients with both diabetes and coccidioidomycosis, a fungal infection common in central California. Researchers found that patients with poorly controlled diabetes (higher HbA1c levels) had higher rates of serious lung disease with cavities and were less likely to recover from the infection. The study highlights that managing blood sugar levels may be just as important as taking antifungal medications when treating this dual condition.

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Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India

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This study describes five cases of a serious fungal infection called mucormycosis that started in the mouth following dental procedures like tooth extraction. All patients had uncontrolled diabetes, which made them vulnerable to this infection. The infection was treated with antifungal medications and surgery, with good recovery. The findings highlight how important it is for dentists to follow strict hygiene practices and for diabetic patients to keep their blood sugar controlled before dental work.

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The expression of fungal CotH, human glucose-regulated protein 78 (GRP78), and predicted miRNAs in macrophages and diabetic mice infected with Rhizopus oryzae

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Mucormycosis is a serious fungal infection caused by Rhizopus oryzae that is particularly dangerous for people with diabetes. This study shows that a fungal protein called CotH3 attaches to a human cell receptor called GRP78, allowing the fungus to invade cells more easily in diabetic patients. The research found that diabetes increases GRP78 production, making fungal invasion more likely, while antifungal treatment (liposomal amphotericin B) can reduce the expression of both CotH3 and GRP78.

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