Research Topic: cognitive function

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

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Researchers identified a gene called NISCH that increases the risk of schizophrenia and bipolar disorder. When this gene is overactive, it changes the shape of connections between brain cells and impairs working memory in mice. Interestingly, blood pressure medications like clonidine can reduce NISCH activity and improve cognitive function, suggesting these drugs might help psychiatric patients.

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Correlation between Vegetable and Fruit Intake and Cognitive Function in Older Adults: A Cross-Sectional Study in Chongqing, China

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This study examined how eating different types of fruits and vegetables affects brain health in older adults in Chongqing, China. Researchers found that higher fruit intake and eating more root vegetables (like carrots and turnips) were associated with better cognitive function and lower risk of mild cognitive impairment. Some vegetables like tomatoes and peppers also showed protective benefits, while leafy greens did not show a significant effect. The findings suggest that encouraging older adults to eat more fruits and certain vegetables could help prevent memory problems and cognitive decline.

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GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

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As we age, brain cells called excitatory neurons undergo senescence, similar to cellular ageing. This study found that a protein called GDF11 protects these neurons from ageing. When GDF11 was removed from excitatory neurons in mice, the neurons aged faster, leading to memory problems and shorter lifespans. The research reveals that GDF11 works by blocking p21, a molecule that promotes cellular ageing.

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Primary cilia in the mature brain: emerging roles in Alzheimer’s disease pathogenesis

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Primary cilia are small hair-like structures on brain cells that act like sensory antennas, helping regulate memory and thinking ability. In Alzheimer’s disease, these structures become abnormally shaped and function poorly, contributing to memory loss and cognitive decline. The shape and function of primary cilia change as the brain ages and when amyloid plaques develop, suggesting they could be targeted with new treatments to slow Alzheimer’s progression.

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