Research Topic: Clinical Mycology

Renaming Candida glabrata—A case of taxonomic purity over clinical and public health pragmatism

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Candida glabrata is a common yeast infection that causes serious illnesses in humans, affecting millions of people worldwide. Scientists have recently proposed renaming it to Nakaseomyces glabrata for technical taxonomic reasons. However, this article argues against the change because it would create confusion for doctors, complicate treatment instructions on medications, disrupt disease tracking systems, and make it harder for patients to understand their conditions. Keeping the familiar name Candida glabrata is more practical and helpful for patient care and public health than strict adherence to taxonomic classification rules.

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Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)

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This study examined dangerous mold infections called mucormycosis that became more common during the COVID-19 pandemic, particularly in Iran. Researchers tested over 180 fungal samples from patients and soil to understand which types of molds cause infections and which antifungal medicines work best against them. They found that two medicines, amphotericin B and posaconazole, were most effective, while fungi from soil samples were often more resistant to treatment than those from infected patients. This research helps doctors choose the right treatments for patients with these serious infections.

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Moving beyond multi-triazole to multi-fungicide resistance: Broader selection of drug resistance in the human fungal pathogen Aspergillus fumigatus

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Aspergillus fumigatus is a dangerous fungal infection treated with triazole drugs, but the fungus is developing resistance to multiple antifungal medications. This resistance appears to be selected in agricultural settings where fungicides are used on crops, and resistant strains then spread to humans through the air. The problem is worse because agricultural fungicides are selecting for strains resistant to multiple drug classes at once, making infections harder to treat. Addressing this issue requires reducing fungicide use in agriculture and better strategies for managing antifungal resistance.

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Utility of MALDI-ToF MS for Recognition and Antifungal Susceptibility of Nannizzia, an Underestimated Group of Dermatophytes

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Nannizzia species are soil-dwelling fungi that increasingly cause stubborn skin, nail, and hair infections in humans and animals. This study tested two laboratory methods for identifying these fungi and measured their sensitivity to eight antifungal drugs. The faster liquid-based method was slightly more accurate (67%) than the traditional culture method (62%), though neither method could identify six very rare species. Terbinafine emerged as the most effective antifungal treatment in laboratory tests.

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