Research Topic: bioactive compounds

Neuroprotective Effects of Mushroom Biomass Digestive Fractions and Gut Microbiota Metabolites in Microglial and Caenorhabditis elegans Models of Neurodegeneration

This study tested whether common and medicinal mushrooms could protect against Alzheimer’s disease by reducing harmful reactive oxygen species in brain cells. Researchers tested three mushroom types using digestive simulation to see what the body could absorb, plus key compounds made by gut bacteria. The mushroom extracts and certain bacterial metabolites successfully reduced cellular damage markers and improved behavior in disease-model worms, suggesting mushroom-rich diets may help prevent neurodegeneration.

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Biotechnological Applications of Mushrooms under the Water-Energy-Food Nexus: Crucial Aspects and Prospects from Farm to Pharmacy

Mushrooms are emerging as a powerful solution for solving global food, water, and energy challenges. Scientists are using biotechnology to produce tiny healing particles from mushrooms, clean up polluted soil and water, create renewable energy, and extract beneficial compounds for medicine and health. This review shows how integrated mushroom farming can help achieve sustainable development goals while reducing waste and supporting human wellbeing.

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Formulation of functional noodles by adding Lentinus edodes mushroom powder: Physiochemical attributes, cellular mineral uptake and improved glycemic index

Researchers developed a healthier version of noodles by adding shiitake mushroom powder at 4% concentration. These mushroom noodles had better nutritional content with more protein and minerals like iron and calcium that the body could actually absorb. Most importantly, the mushroom noodles caused a slower, more gradual rise in blood sugar compared to regular noodles, making them potentially beneficial for people managing diabetes.

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Comparative Analysis of Freeze-Dried Pleurotus ostreatus Mushroom Powders on Probiotic and Harmful Bacteria and Its Bioactive Compounds

Researchers studied oyster mushrooms processed in different ways to understand their health benefits. The study found that cooked oyster mushroom powders can kill harmful bacteria and promote the growth of beneficial gut bacteria. These mushrooms also contain special particles called carbon nanodots that form during cooking and may enhance their health-promoting effects. The findings suggest oyster mushrooms could help maintain a healthy gut microbiota naturally.

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Antioxidant, Antibacterial and Dyeing Potential of Crude Pigment Extract of Gonatophragmium triuniae and Its Chemical Characterization

Scientists discovered a rare orange-pigment-producing fungus called Gonatophragmium triuniae that has useful medicinal and practical applications. The fungus produces a natural pigment that can kill bacteria, protect against oxidative damage, and effectively dye cotton fabrics without toxic chemicals. The main active compound was identified as a phenoxazine derivative, suggesting potential uses in textiles, pharmaceuticals, and natural cosmetics as a safe alternative to synthetic pigments and antibiotics.

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Clinical Isolate of Candida tropicalis from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of Ganoderma lucidum

Researchers in North Carolina identified a drug-resistant yeast infection (Candida tropicalis) from a hospital patient and tested whether extracts from reishi mushrooms (Ganoderma lucidum) could kill it. Using genetic analysis, they found mutations in the yeast that help it resist antifungal drugs. All three types of mushroom extracts tested successfully stopped the yeast’s growth and damaged its cells, suggesting that reishi mushrooms could be a promising natural treatment option for hard-to-treat candida infections.

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Advancing Pistacia terebinthus L. (Anacardiaceae) Research: Food Preservation, Functional Foods, and Nutraceutical Potential

The turpentine tree (Pistacia terebinthus L.) is a Mediterranean plant traditionally used in food and medicine that is now being studied for modern food applications. Its fruits, seeds, leaves, and resin contain powerful compounds that fight bacteria, reduce oxidative stress, and promote health. Scientists are developing new techniques like microencapsulation and fermentation to preserve its beneficial properties in functional foods, yogurt, and other products. This underutilized plant could become an important natural ingredient for food preservation and health supplements.

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Biologically active secondary metabolites from white-rot fungi

White-rot fungi are special mushrooms that can break down wood and produce unique chemical compounds with amazing health benefits. These compounds have been found to fight cancer, kill harmful bacteria, reduce inflammation, and protect nerve cells. Scientists are excited about using these natural fungal compounds to create new medicines and treat various diseases in the future.

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Evaluation of Two Different Treatments for Larch Logs as Substrates to Cultivate Ganoderma tsugae in the Forest

This study compared growing the medicinal mushroom Ganoderma tsugae on sterilized versus non-sterilized larch wood in a forest setting. Researchers found that non-sterilized wood actually produced mushrooms with higher levels of beneficial compounds like triterpenoids and polysaccharides, while requiring less processing and cost. These findings suggest that farmers can use a simpler, less expensive cultivation method while still producing high-quality medicinal mushrooms.

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Soy Sauce Fermentation with Cordyceps militaris: Process Optimization and Functional Profiling

Researchers created a new type of soy sauce using Cordyceps militaris fungus, which contains health-promoting compounds. Using scientific optimization techniques, they found the best conditions for fermentation, resulting in a soy sauce with much higher levels of cordycepin and other beneficial compounds compared to traditional soy sauce. This product offers both the familiar taste of soy sauce and added health benefits, potentially serving as a functional food that people can use daily.

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