Research Topic: anxiety disorders

Decreases in State and Trait Anxiety Post-psilocybin: A Naturalistic, Observational Study Among Retreat Attendees

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This study followed 52 people who attended psilocybin retreats in the Netherlands and measured their anxiety levels before, one day after, and one week after the experience. Participants showed significant reductions in both immediate anxiety (state anxiety) and long-term anxiety tendencies (trait anxiety) that lasted up to a week. The anxiety improvements were most strongly linked to feeling a sense of ego dissolution during the experience and to lasting changes in personality traits, particularly becoming less neurotic.

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Identification of Blood Biomarkers of Psilocybin-Assisted Therapy Treatment Response for Generalised Anxiety Disorder

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Researchers studied how psilocybin-assisted therapy works for people with anxiety disorders by examining blood samples from patients who responded well to treatment versus those who didn’t. They identified four genes whose expression patterns could help predict which anxiety patients would benefit from psilocybin therapy before starting treatment. This breakthrough could help doctors avoid giving intensive treatment to patients unlikely to respond and instead direct them toward more effective alternatives.

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Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders

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This comprehensive review explores how psychedelic drugs like psilocybin mushrooms, DMT, and LSD may offer new hope for treating depression, anxiety, and PTSD, especially for patients who don’t respond to conventional antidepressants. Historically used in spiritual ceremonies for thousands of years, these compounds are now being scientifically studied and show promise with fewer side effects than many traditional psychiatric medications. The authors emphasize that while results are encouraging, more research and regulatory approval are needed before these treatments become widely available in mainstream medicine.

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The psychedelic-peptide paradox: a hormetic hypothesis

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This review explores how psychedelic drugs like LSD and psilocybin work through the body’s natural stress-response systems, particularly two brain chemicals called oxytocin and vasopressin. It explains why psychedelics initially cause uncomfortable feelings like nausea and anxiety, but these are followed by improved mood, sociability, and emotional healing. The theory suggests that this initial ‘stress’ response triggers the body’s natural healing mechanisms, similar to how physical exercise makes you uncomfortable initially but builds strength over time.

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