Antifungal therapy – Page 8

A rare case of invasive necrotizing myositis of the thigh caused by Basidiobolus ranarum: a multi-pronged approach to successfully managing a near-fatal polybacterial mycotic infection

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A 46-year-old man developed a severe fungal infection caused by a rare fungus called Basidiobolus ranarum in his thigh, which started from an insect bite two years earlier. The infection caused tissue death and was complicated by bacterial superinfection, requiring aggressive treatment with multiple antibiotics and antifungal medications along with several surgeries. Doctors used a combination approach including voriconazole, potassium iodide, and itraconazole to finally control the infection, though amputation was necessary due to the extent of tissue damage. The case highlights the importance of early medical care and demonstrates that rare fungal infections can be life-threatening even in otherwise healthy people.

Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland

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This research examined how pediatric cancer hospitals in Germany, Austria, and Switzerland manage fungal infections, which are a serious risk for children undergoing cancer treatment. The survey found that while most hospitals have infection specialists and antifungal prevention strategies, there are significant differences in how they diagnose and treat these infections. The study identified key challenges like drug interactions and delays in testing, and suggests that better networks between cancer and infection specialists could improve patient care.

Randomized control trial to study the effectiveness of tablet Fluconazole, capsule Itraconazole and tablet Terbinafine in superficial dermatophytosis

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This study tested three common antifungal medications used to treat fungal skin infections like ringworm. The research involved 180 patients who were randomly given one of three drugs and then checked at 4 and 8 weeks to see if the infection was gone. Itraconazole worked best, clearing infections in about 87% of patients, followed by Fluconazole at 73%, and Terbinafine at 63%.

Histoplasma capsulatum prosthetic valve endocarditis treated with oral isavuconazole

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A 76-year-old man developed a rare fungal infection of his artificial heart valve caused by Histoplasma capsulatum. After surgically replacing the infected valve, he was treated with isavuconazole, an antifungal medication taken by mouth. Unlike traditional antifungal treatments, isavuconazole was better tolerated and easier to take. The patient successfully recovered after nine months of treatment with no complications.

Urosepsis From Nephrolithiasis Caused by Candida glabrata: A Rare Etiology of Urinary Sepsis in an Immunocompetent Patient

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A 41-year-old man with kidney stones developed a serious bloodstream infection caused by Candida glabrata, a type of yeast fungus that rarely infects healthy people. Although he initially received antibiotics, his condition worsened until doctors identified the fungal infection through blood tests. After placing a drainage tube in his kidney and treating him with an antifungal medication called micafungin, he recovered well. This case highlights the importance of considering fungal infections when standard antibiotics fail to treat kidney stone-related infections.

Candida krusei Empyema: A Lung Transplant Case and Systematic Review of the Literature

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Candida krusei is a dangerous fungus that can cause fluid buildup around the lungs (empyema), particularly in transplant patients. Unlike common fungal infections that respond to fluconazole, this species is naturally resistant to this drug, making it harder to treat. The fungus forms protective biofilms that shield it from treatment, requiring combination antifungal medications and sometimes surgery to drain the fluid and remove infected tissue for successful recovery.

Efficacy of Rezafungin on Candida albicans Endophthalmitis in a Rabbit Model

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Researchers tested a new antifungal drug called rezafungin against a serious eye infection caused by Candida fungus in rabbits. Rezafungin performed much better than two other commonly used antifungal drugs, completely eliminating the fungus from the eye while preventing infection-related damage. The drug’s ability to be given weekly instead of daily makes it more practical for treating patients with severe fungal eye infections.

A case report of disseminated histoplasmosis not responding to primary treatment by itraconazole

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A healthy 28-year-old woman developed a serious fungal infection caused by Histoplasma capsulatum after dental surgery. The standard antifungal medication (itraconazole) did not work for her, even at high doses. Doctors successfully treated her with a more powerful antifungal drug called liposomal amphotericin B, which cleared the infection completely. This case shows the importance of adjusting treatment when patients don’t respond to initial therapy.

Rhino sinusitis caused by Lasiodiplodia theobromae in a diabetic patient

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A 56-year-old diabetic man developed a sinus infection caused by a rare fungus called Lasiodiplodia theobromae, which typically affects plants. The infection was diagnosed through laboratory testing and DNA sequencing, as traditional identification methods were inconclusive. The patient was successfully treated with a combination of sinus surgery and a six-week course of antifungal medication, showing complete recovery after one year of follow-up.

Disseminated Scedosporium boydii infection with pulmonary and cerebral involvement in a patient with COPD: A case report

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A 51-year-old man with chronic lung disease developed a life-threatening brain infection caused by a rare fungus called Scedosporium boydii. The infection started in his lungs and spread to his brain, causing a fluid-filled abscess. Despite treatment with antifungal medications and surgery, the patient died because the initial treatment was incomplete and the infection had time to progress to his brain.

Research Topic: Antifungal therapy