Antifungal therapy – Page 7

Coexistence of Malassezia Species and Microsporum canis in the Lesions of Adult with Tinea Capitis

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A 60-year-old woman developed unusual hair loss and rash on her scalp that looked like dandruff. Tests revealed three types of fungi, including Microsporum canis (usually found in animals) and two types of Malassezia yeast. Treatment with antifungal medications for three months cleared the infection. Laboratory experiments showed that the yeast species may actually help the fungus grow better, which could explain why adults sometimes get scalp fungal infections differently than children.

Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review

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Cystic fibrosis is a serious genetic disease affecting children that damages the lungs through chronic infections. Aspergillus, a common mold in the environment, colonizes the airways of CF patients and can cause additional lung damage. While new CFTR modulator medications have improved outcomes and reduced Aspergillus infections, more research is needed to better diagnose and treat fungal infections in children with CF.

Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India

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This case series describes five patients from India who developed a serious fungal infection in their jaw and mouth after dental procedures. All patients had uncontrolled diabetes, which weakened their immune system and allowed the fungus to grow. The infection was treated with anti-fungal medications and surgery, and most patients recovered well. The study emphasizes the importance of keeping dental equipment sterile and managing blood sugar levels properly before dental work.

Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing

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A patient with a serious fungal infection of the sinuses caused by Rhizopus arrhizus received the antifungal drug isavuconazole. However, blood tests showed the drug was building up to dangerously high levels in her body. Genetic testing revealed she had a mutation that made her body unable to break down the drug normally. The doctors had to give her much smaller and less frequent doses while carefully monitoring her drug levels to keep her safe.

Epidermophyton floccosum, an etiological agent of tinea pedis and tinea unguium: about two cases

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Two elderly patients were diagnosed with fungal nail and foot infections caused by Epidermophyton floccosum, a fungus that has become less common in recent years. Both cases were confirmed using advanced molecular testing (real-time PCR) alongside traditional laboratory methods. The infections were successfully treated with terbinafine, an antifungal medication. This case report highlights the importance of using modern diagnostic techniques to accurately identify and treat fungal infections.

Data analysis of patients with positive mould or dimorphic fungal cultures from sterile sites

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This study examined 48 patients with serious mould and fungal infections at a South African hospital between 2014-2017. Most infections occurred in people with weak immune systems, especially those with HIV. The most common fungal type was Aspergillus. Even with appropriate antifungal medicines, one-quarter of patients died, highlighting how serious these infections can be.

Invasive fungal otitis media with peripheral facial paralysis

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This case describes a rare fungal ear infection caused by Aspergillus fumigatus that spread to the mastoid bone and caused facial nerve paralysis. The patient had ear drainage and hearing loss for 4 years before diagnosis. Treatment required two surgical procedures to remove infected tissue combined with 6 months of antifungal medication, eventually resulting in healing and recovery of facial nerve function.

Clinical Significance and Therapeutic Challenges of Scedosporium spp. and Lomentospora prolificans Isolates in a Single-Center Cohort of Lung Transplant Recipients

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This study examined dangerous fungal infections caused by Scedosporium and Lomentospora species in lung transplant patients at a Spanish hospital. Researchers found these infections were uncommon but very serious, with high death rates especially from the Lomentospora type. Current antifungal drugs often don’t work well against these fungi, highlighting the need for better treatment options.

Two Cases of Curvularia geniculata Keratitis Successfully Treated with Natamycin-Based Therapy

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Two patients with eye infections caused by a rare fungal species called Curvularia geniculata were successfully treated with antifungal medication. The infections occurred after plant material entered their eyes during daily activities. Doctors identified the exact fungal species through genetic testing and used an antifungal drug called natamycin, alone or combined with another antifungal, to treat the infections. Both patients recovered fully with excellent vision restoration.

Clinical spectrum, immune status, and prognostic factors of cryptococcosis: insights from a large, multi-center, ambispective cohort study in southeastern China

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This study examined cryptococcosis, a serious fungal infection, in 396 non-HIV patients across hospitals in southeastern China. The researchers found that patients’ immune status, whether the infection spread to the brain, and blood inflammation markers were key predictors of survival. Most patients treated with azole medications (a common antifungal) improved or recovered, though those with brain involvement or severe immune deficiency had worse outcomes. The findings help doctors identify which patients need more intensive treatment.

Research Topic: Antifungal therapy