structure-function analysis

Structural and functional characterisation and regulatory mechanisms of SWI/SNF and RSC chromatin remodelling complexes in fungi

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This review examines two important protein complexes in fungal cells that help control which genes are turned on and off. These complexes, called SWI/SNF and RSC, use energy from ATP to move and adjust nucleosomes—the structures that package DNA. The researchers analyzed these complexes across different fungal species and found that while they share similar core components, fungi have evolved unique variations that allow them to survive and cause infections in different ways. Understanding how these complexes work could help scientists develop new antifungal drugs.

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

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Researchers discovered that a toxic protein from edible mushrooms called VVA2 has a hidden ability to cut double-stranded DNA. When modified to remove its toxic effects, this protein became a powerful DNA-cutting enzyme that works best at warm temperatures and requires specific metal ions to function. This discovery could have practical applications in DNA research and diagnostic testing.

Research Topic: structure-function analysis

Structural and functional characterisation and regulatory mechanisms of SWI/SNF and RSC chromatin remodelling complexes in fungi

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease