proteases – mycolab.ai

Potential Roles of Exogenous Proteases and Lipases as Prebiotics

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This review explores how digestive enzymes like proteases and lipases work similarly to prebiotics—foods that feed beneficial bacteria in your gut. When animals consumed supplements of these enzymes, their gut bacteria became healthier, producing more beneficial compounds and showing improved intestinal health. These findings suggest that fermented foods and raw foods containing natural digestive enzymes, as well as enzyme supplements, may help promote a healthy gut microbiome.

Activation of Secondary Metabolism and Protease Activity Mechanisms in the Black Koji Mold Aspergillus luchuensis through Coculture with Animal Cells

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Researchers found that growing koji mold (Aspergillus luchuensis) alongside mouse immune cells in the laboratory significantly increases the production of valuable bioactive compounds. The mold releases enzymes called proteases that break down proteins from the animal cells, which the fungus then uses as building blocks to create medicinal compounds. This discovery shows that coculturing microorganisms with animal cells is an effective strategy to unlock hidden chemical production capabilities in fungi, which could lead to new medicines and useful compounds.

Dermatophytes adaptation to the human host exemplified by Microsporum canis

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Researchers studied how fungi that normally infect cats and dogs are adapting to infect humans. By comparing the genes of zoophilic (animal-loving) and anthropophilic (human-loving) Microsporum species, they found that human-adapted strains have developed specific proteins that help them survive in the acidic environment of human skin. These fungi have evolved special enzymes for breaking down keratin and tolerating the lipid-rich, acidic conditions of human skin better than their animal-loving relatives.

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

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This study examined how a fungal protein called SUB6 helps dermatophytes (fungi causing ringworm) stick to human skin. Researchers used genetically modified fungi without SUB6 and found that these strains had difficulty initially attaching to skin but eventually infected it anyway. The results suggest SUB6 is a useful marker for detecting fungal infections but isn’t absolutely necessary for the fungus to cause disease.

Research Topic: proteases

Potential Roles of Exogenous Proteases and Lipases as Prebiotics

Activation of Secondary Metabolism and Protease Activity Mechanisms in the Black Koji Mold Aspergillus luchuensis through Coculture with Animal Cells

Dermatophytes adaptation to the human host exemplified by Microsporum canis

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis