Research Topic: Polyketides

Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research

Mushrooms and related fungi in the basidiomycete group produce many useful medicines and agricultural chemicals. Scientists have traditionally struggled to study these fungi because they grow slowly and have complex genomes. Recent technological breakthroughs—including faster DNA sequencing and gene-editing tools—are now making it much easier to discover and understand the helpful compounds these fungi produce, potentially leading to new medicines.

Read More »

Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites

Scientists have learned to use common baker’s yeast (S. cerevisiae) as a biological factory to produce valuable medicines and compounds that naturally come from fungi and mushrooms. By transferring the genetic instructions for making these compounds into yeast cells and improving them with genetic engineering, researchers can now produce therapeutically important substances like cancer-fighting drugs and antibiotics in large quantities. This approach is more practical and cost-effective than trying to extract these rare compounds directly from their native fungal sources or using other production methods.

Read More »

Deletion of bZIP Transcription Factor PratfA Reveals Specialized Metabolites Potentially Regulating Stress Response in Penicillium raistrickii

Scientists discovered that a protein called PratfA controls the production of protective compounds in a fungus (Penicillium raistrickii) that help it survive stress. By removing this protein, they found two new natural products, including one with an unusual structure. The fungus without PratfA became very sensitive to oxidative stress and couldn’t survive well, showing that this protein is important for both making protective compounds and surviving harsh conditions.

Read More »
Scroll to Top