Research Topic: polyketide biosynthesis

Unprecedented Mushroom Polyketide Synthases Produce the Universal Anthraquinone Precursor

Scientists discovered that mushrooms in the Cortinarius genus use unique enzymes called polyketide synthases to produce chemical building blocks that become anthraquinone compounds. These mushroom enzymes work differently from similar enzymes found in molds and plants, showing that nature independently invented multiple ways to make the same important molecules. This finding reveals how different organisms evolved similar chemical-making abilities through completely different evolutionary paths, and suggests this principle applies to many other mushroom species as well.

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Transformation of Alternaria dauci demonstrates the involvement of two polyketide synthase genes in aldaulactone production and fungal pathogenicity

A fungus that causes leaf spots on carrots produces a toxic chemical that helps it infect plants. Scientists identified two genes responsible for making this toxin and used genetic engineering to create mutant fungi unable to produce it. When these mutant fungi tried to infect carrot plants, they were much less damaging than the normal fungus, proving the toxin is crucial for the fungus to cause disease.

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Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23

Scientists discovered two new antimicrobial compounds called pyrrolomycins from bacteria living in termites using genome sequencing and chemical analysis. These compounds contain chlorine atoms and are related to known antibiotics. The research shows how the bacteria protects itself from its own antimicrobial compounds through chemical modifications, offering insights into developing new antibiotics.

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