Research Topic: neurotoxicity

Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report

A 17-year-old girl became severely ill after eating a chocolate bar containing a medicinal mushroom product that was contaminated with muscimol, a toxic compound from poisonous mushrooms. She experienced confusion, uncontrollable muscle jerks, dilated pupils, and excessive drooling, requiring hospitalization and temporary breathing assistance. Though her symptoms resolved within 8 hours and she recovered fully, this case highlights the serious danger of unregulated mushroom supplements that can be contaminated with deadly toxins.

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Intrinsic determinants of prion protein neurotoxicity in Drosophila: from sequence to (dys)function

Prion diseases are deadly brain conditions caused by misfolded proteins. This study used computer simulations and fruit fly experiments to understand how tiny changes in prion protein structure affect its ability to cause disease. Researchers found that proteins with flexible loops are more toxic, while those with more rigid structures cause less damage, suggesting new ways to develop treatments by stabilizing the protein’s structure.

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