Research Topic: iron metabolism

Exploring the Siderophore Portfolio for Mass Spectrometry-Based Diagnosis of Scedosporiosis and Lomentosporiosis

Two dangerous opportunistic fungi that cause serious infections in vulnerable patients produce distinct chemical compounds called siderophores to help them acquire iron from their hosts. Researchers used advanced mass spectrometry techniques to detect and measure these compounds, finding that one fungus produces significantly more of these iron-scavenging molecules, which may explain why it causes more severe infections. These siderophores could potentially be used as diagnostic markers in medical laboratories to quickly identify these infections in patient samples.

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A human-relevant alternative infection model for mucormycosis using the silkworm Bombyx mori

Researchers developed a silkworm-based model to study mucormycosis, a deadly fungal infection. The model reproduces the same disease patterns and risk factors seen in humans, including effects of steroids and iron levels. Importantly, it successfully predicted how well antifungal drugs work against the infection, offering a faster and more ethical alternative to mammal testing for developing new treatments.

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