Research Topic: invasive mycosis

Exploring the Siderophore Portfolio for Mass Spectrometry-Based Diagnosis of Scedosporiosis and Lomentosporiosis

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Two dangerous opportunistic fungi that cause serious infections in vulnerable patients produce distinct chemical compounds called siderophores to help them acquire iron from their hosts. Researchers used advanced mass spectrometry techniques to detect and measure these compounds, finding that one fungus produces significantly more of these iron-scavenging molecules, which may explain why it causes more severe infections. These siderophores could potentially be used as diagnostic markers in medical laboratories to quickly identify these infections in patient samples.

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Invasive Rhinocerebral Mucormycosis Is a Rare Complication in Systemic Juvenile Idiopathic Arthritis Patient

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A 5-year-old girl with a serious joint disease called systemic juvenile idiopathic arthritis developed a dangerous fungal infection in her nasal cavity and brain area. The fungal infection, caused by a mold organism called Lichtheimia, occurred because her immune system was severely weakened by medications used to treat her arthritis. Doctors treated the infection with antifungal drugs and surgery, and the patient eventually recovered by switching to a different arthritis medication. This case highlights how the strong medications needed to control some childhood arthritis can unexpectedly cause serious fungal infections.

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Evaluating the Potential of Galactosaminogalactan as a Diagnostic Target for Invasive Aspergillosis

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Researchers developed a new test to detect invasive fungal infections caused by Aspergillus by targeting a molecule called galactosaminogalactan (GAG) on the fungus surface. The test worked very well in mice with the infection and showed better specificity than current methods. However, the test did not detect GAG in blood or other body fluids from human patients, suggesting that additional research is needed before it can be used clinically.

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