high-throughput screening

Screening of a Fraction with Higher Amyloid β Aggregation Inhibitory Activity from a Library Containing 210 Mushroom Extracts Using a Microliter-Scale High-Throughput Screening System with Quantum Dot Imaging

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Researchers screened 210 mushroom species from Japan to find those that could prevent harmful protein clumping in the brain associated with Alzheimer’s disease. They identified a purified fraction from the mushroom Elfvingia applanata that was more effective than a known anti-Alzheimer’s compound at stopping these protein clumps from forming. The extract also protected nerve cells from damage in laboratory tests. This finding suggests mushrooms could potentially be developed into a functional food to help prevent Alzheimer’s disease.

High‐Throughput Culture and DNA Isolation Methods for Aspergillus fumigatus

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Scientists have developed a faster, cheaper way to grow and extract DNA from Aspergillus fumigatus, a fungus that causes serious infections in sick people. Using 96-well plates (the same format used in many laboratories), researchers can now process many samples at once instead of handling them one by one. The method works well for identifying drug-resistant fungal strains and preparing DNA for genetic analysis.

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective

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Traditional medicines from plants, animals, and fungi contain chemical compounds that can interact with specific proteins in our cells called G protein-coupled receptors (GPCRs). These receptors control many important body functions and are targeted by about one-third of all FDA-approved medications. This review explains how scientists are discovering new therapeutic compounds from traditional medicines by systematically screening them against the complete library of human GPCRs, using advanced techniques to identify which compounds bind to which receptors. Famous examples include morphine from poppies for pain relief and compounds from ginseng that help regulate blood sugar.

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

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Scientists developed a fast, automated method called FLECS-96 to screen hundreds of fungal species for antimicrobial compounds in a small 96-well plate format. The method combines fungal culture, chemical extraction, and analysis to identify promising candidates against resistant bacteria like Staphylococcus aureus. The team successfully identified two bioactive compounds from the fungi tested. This innovation could significantly speed up the discovery of new antibiotics to combat antibiotic-resistant infections.

A novel pan-fungal screening platform for antifungal drug discovery: proof of principle study

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Researchers developed a faster, more efficient screening method to test potential antifungal drugs against multiple disease-causing fungi simultaneously. Using an improved growth medium and screening 500 chemical fragments, they identified compounds with antifungal activity and demonstrated the platform can reliably detect promising drug candidates. This approach could accelerate the discovery of new antifungal medications, which are urgently needed as fungi develop resistance to current treatments.

Research Topic: high-throughput screening

Screening of a Fraction with Higher Amyloid β Aggregation Inhibitory Activity from a Library Containing 210 Mushroom Extracts Using a Microliter-Scale High-Throughput Screening System with Quantum Dot Imaging

High‐Throughput Culture and DNA Isolation Methods for Aspergillus fumigatus

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

A novel pan-fungal screening platform for antifungal drug discovery: proof of principle study