Research Topic: hepatotoxicity

Ganoderma lingzhi (Reishi Mushroom)-Induced Acute Liver Injury in the Setting of Alcohol Use: A Case Report and Review of the Literature

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A 47-year-old man developed severe liver inflammation after consuming Reishi mushroom powder while drinking large amounts of vodka over three days. Although Reishi mushrooms are commonly promoted as healthy supplements, in this case the combination with alcohol caused his liver enzymes to spike dangerously high. The patient recovered after hospital treatment, but the case highlights that even natural supplements can be harmful, especially when combined with alcohol. This raises concerns that more research is needed on how mushroom supplements interact with other substances people consume.

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Isavuconazonium Utilization in Pediatric Patients at a Free-Standing Children’s Hospital

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Researchers at Children’s Hospital Los Angeles studied how well a newer antifungal medication called isavuconazonium works in children with cancer and blood disorders who are at high risk for serious fungal infections. The medication was recently approved for use in children ages 1 and older. The study found that the medication was generally safe and effective, though doctors need to monitor liver function and drug levels to ensure proper dosing and catch any side effects early.

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Herbal Supplement-Induced Liver Injury: A Case Report

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A 45-year-old woman developed severe liver injury after drinking an herbal tea containing multiple ingredients, including reishi mushroom and aloe vera. Her liver function gradually improved after she stopped drinking the tea, with complete recovery within three months. This case demonstrates that herbal supplements, often perceived as safe, can cause serious liver damage and should be investigated when patients develop unexplained liver problems.

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A Rare Case of Methyldopa-Induced Hepatitis

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A 31-year-old woman developed severe liver inflammation (hepatitis) six weeks after starting methyldopa, a common blood pressure medication. After stopping the drug, her liver function returned to normal without needing steroids or other intensive treatments. This case reminds doctors that even commonly used, safe medications can rarely cause serious liver problems and should be considered when patients develop unexplained liver inflammation.

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