Research Topic: heart transplantation

Invasive Fungal Infections in Orthotopic Heart Transplant Patients: Incidence and Risk Factors in the Modern Era

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This study examined fungal infections in heart transplant patients at Cleveland Clinic between 2010-2020. Researchers found that about 5% of heart transplant patients developed serious fungal infections, with Candida being the most common culprit. Patients with previous fungal infections, those who needed additional surgeries after transplant, and those requiring life support machines (ECMO) had the highest risk. Heart transplant patients with fungal infections had much worse survival rates, suggesting the need for better prevention strategies using antifungal medications.

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The first described case of Fomitiporella micropora infection in humans: A heart transplant recipient diagnosed by fungal PCR

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A heart transplant patient developed a slow-growing lump on his shin that turned out to be caused by a rare fungus never before seen in humans. Doctors removed the lump surgically and used advanced genetic testing to identify the unusual fungus as Fomitiporella micropora. The patient received antifungal medication and the wound healed completely, highlighting how modern genetic tests can identify rare infections that traditional methods might miss.

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The first described case of Fomitiporella micropora infection in humans: A heart transplant recipient diagnosed by fungal PCR

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A patient who received a heart transplant developed a small, slowly-growing lump on his shin over many years. After surgical removal, genetic testing revealed it was caused by a rare fungus never before identified in humans. The surgical removal likely cured the infection, and the case shows how important advanced genetic testing methods are for identifying unusual infections in transplant patients.

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The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients

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This case report describes two rare instances where fungal infections were transmitted from organ donors to heart transplant recipients. One involved a Candida infection and the other involved Aspergillus fungus, both causing serious bloodstream and heart infections. The patients required extensive antifungal medications and multiple surgeries to survive their infections, though they experienced significant complications. These cases highlight the importance of careful screening of organ donors for undetected infections.

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