Research Topic: genomic plasticity

Evolutionary Dynamics and Functional Bifurcation of the C2H2 Gene Family in Basidiomycota

Researchers studied C2H2 genes, which are master regulators controlling important processes in fungal cells, across 30 different mushroom and fungal species. They found that these genes evolved differently depending on whether fungi were decomposers (saprotrophs) or pathogens, with decomposers maintaining more complex gene structures. During mushroom development in Sarcomyxa edulis, different C2H2 genes became active at different stages, controlling temperature adaptation, fruiting body formation, and other developmental processes.

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Candida albicans bloodstream infections are comprised of diverse populations of strains, including antifungal tolerant strains that emerge during treatment failure

Researchers found that Candida albicans bloodstream infections contain multiple different strains, not just one strain as previously thought. Some strains are more tolerant to antifungal medications like micafungin, and when treatment is started, the drug-tolerant strains can be eliminated while drug-sensitive strains increase in number. This discovery suggests that treatment failures may occur because pre-existing drug-resistant strains are selected for during treatment.

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