Research Topic: extracellular matrix

Enhanced biodegradation of fluorinated pharmaceutical by Aspergillus flavus and Cunninghamella elegans biofilms: kinetics and mechanisms

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Two types of fungi, Aspergillus flavus and Cunninghamella elegans, can effectively break down pharmaceutical pollutants commonly found in wastewater, such as antidepressants and antibiotics. When grown as biofilms on foam carriers, these fungi removed over 90% of the target pharmaceuticals very quickly. The fungi accomplish this primarily through enzymatic breakdown rather than absorption, making them promising candidates for cleaning wastewater at treatment plants.

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Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

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Scientists discovered that a protein called TIMP2, which is naturally higher in young blood, plays a crucial role in maintaining brain memory and learning ability. Using laboratory mice, they found that TIMP2 helps keep the brain’s cellular environment flexible by controlling the buildup of structural proteins around nerve connections. Without adequate TIMP2, the brain develops more rigid connections that interfere with forming new memories and creating new brain cells, mimicking changes seen in aging and cognitive decline.

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Characterization of Biofilm Formation by the Dermatophyte Nannizzia gypsea

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This study examined how Nannizzia gypsea, a fungus that causes skin infections in humans and animals, forms protective biofilms that make it resistant to antifungal drugs. Researchers found that the fungus creates a robust protective layer with specific molecular components and highly expresses genes related to virulence and drug resistance when in biofilm form. These findings help explain why dermatophyte infections are difficult to treat and recur frequently.

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Scanning electron microscopy of hyphal ectobiont bacteria within mycelial extracellular matrices

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Researchers studied how bacteria attach to fungal filaments using advanced microscopy. They developed a special preparation method that removed outer biofilm layers to reveal how bacteria stick to fungal structures. The study found that bacteria form attachment structures with the fungal surface, with these structures being primarily produced by the fungus. This research helps us understand how bacteria and fungi interact in nature and in biotechnology.

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