Research Topic: ergosterol metabolism

Multi-omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance

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Researchers studied how the fungus Candida auris develops resistance to amphotericin B, an important antifungal drug. By evolving two laboratory strains of this fungus under drug pressure, they discovered two different ways the fungus can become resistant: one through stress management genes, the other through changes in its protective lipids. These findings help explain why some clinical infections with this dangerous fungus are so hard to treat.

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Aspergillus fumigatus ctf1 – a novel zinc finger transcription factor involved in azole resistance

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Researchers discovered that a gene called ctf1 in a harmful fungus called Aspergillus fumigatus helps control how resistant the fungus is to antifungal medications like voriconazole. When this gene is removed, the fungus becomes more resistant to these drugs because it pumps them out more efficiently. Understanding this mechanism could help doctors develop better treatments for serious fungal infections in vulnerable patients.

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The Kelch Repeat Protein VdKeR1 Is Essential for Development, Ergosterol Metabolism, and Virulence in Verticillium dahliae

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Verticillium dahliae is a serious fungal disease that kills many important crops like cotton and tomato by clogging their water-conducting vessels. Scientists discovered a protein called VdKeR1 that helps this fungus grow and cause disease by controlling how it makes ergosterol, a crucial component of fungal cell membranes. When researchers removed this protein, the fungus grew poorly, couldn’t form survival structures, and was much less dangerous to plants.

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