Research Topic: diagnostic criteria

ABPA in post-tuberculosis lung disease: A diagnostic pitfall or genuine entity?

This article addresses confusion between two Aspergillus lung infections that commonly occur after tuberculosis: ABPA and CPA. While they have overlapping symptoms and test results, they require different treatments—ABPA responds to short-term steroids while CPA needs prolonged antifungal drugs. Importantly, giving steroids for misdiagnosed CPA can be harmful, so doctors should be cautious about diagnosing ABPA in tuberculosis survivors and consider CPA instead.

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The 2024 International Society for Human and Animal Mycology (ISHAM)-ABPA working group guidelines: Transforming diagnosis and management of ABPA

ABPA is a serious lung disease that develops when the body overreacts to a common fungus called Aspergillus. New international guidelines help doctors better diagnose and treat this condition, which affects many people with asthma and cystic fibrosis. The guidelines make diagnosis easier by using simpler tests and lowering the thresholds for detecting the disease, and they provide clear treatment plans depending on how severe each patient’s disease is. These updated standards are especially important in countries like India where ABPA is very common.

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COVID-19-associated Pulmonary Aspergillosis in Mechanically Ventilated Patients at 7 US Hospitals: Epidemiology and Estimated Likelihood of Invasive Pulmonary Aspergillosis—Results of the Prospective MSG-017 Study

A fungal infection caused by Aspergillus commonly occurs in COVID-19 patients on ventilators, affecting about 7% of cases. The study found that having this infection was linked to high death rates, but it was unclear whether the fungal infection itself or the severe COVID-19 caused the deaths. Single positive test results for the fungus are not reliable for diagnosis, and antifungal drugs did not improve survival rates.

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