corneal infection – mycolab.ai

A 3D Fusarium keratitis model reveals isolate-specific adhesion and invasion properties in the Fusarium solani species complex

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Researchers studied three species of Fusarium fungus that cause serious eye infections. They found that one species (F. keratoplasticum) is much more dangerous than the others, invading deeper into the eye and causing more damage. Using a new 3D model that mimics the structure of the human cornea, they discovered that Fusarium fungi penetrate much deeper than other fungal pathogens, which helps explain why eye infections from these fungi are so difficult to treat and why patients often lose their vision.

Fungal Keratitis Caused by Humicola sardiniae

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A 78-year-old man developed a serious fungal eye infection caused by Humicola sardiniae, a fungus rarely seen in humans. The infection was difficult to treat because the fungus was resistant to most antifungal medications, and continued use of steroid eye drops worsened the condition. After switching to appropriate antifungal treatment and stopping the steroids, the patient’s cornea eventually healed over four months, though this was the first documented case of this particular fungus infecting a human.

Fusarium Corneal Abscess: A Case Report

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A healthy 20-year-old man developed a serious fungal eye infection caused by Fusarium, a soil fungus, despite having no typical risk factors like eye injury or contact lens wear. Doctors diagnosed the infection through laboratory tests showing fungal filaments and growing the organism in culture. The patient required multiple treatments including antifungal eye drops, injections directly into the cornea, and a graft from amniotic membrane (placenta tissue) to save his vision. The case demonstrates that fungal eye infections can occasionally occur in completely healthy people without obvious causes.

Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights from Candida albicans and Fusarium falciforme

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This study compared how two different fungi invade the cornea (clear part of the eye) by examining tissue samples from patients who had severe eye infections. Candida stayed in one small area while Fusarium spread throughout the entire cornea tissue. The findings suggest that different fungi behave very differently when infecting the eye, which could help doctors choose better treatments. Understanding these differences may explain why Fusarium infections are much harder to treat with medications alone.

Phaeoacremonium iranianum – a new corneal pathogen

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A 66-year-old man developed a serious eye infection from a fungus called Phaeoacremonium iranianum after his eye was scratched by a leaf. This is the first reported case of this fungus causing a corneal infection. Doctors treated the infection with antifungal eye drops and surgery to remove infected tissue, and the patient’s condition improved over time, though with some permanent scarring of the cornea.

A case of corneal infection with Clonostachys rosea

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A 53-year-old patient developed a serious eye infection caused by a fungus called Clonostachys rosea, which had never been reported before as causing eye disease. The infection caused a painful ulcer on the cornea (the clear front part of the eye). Doctors treated the infection with antifungal medications applied as eye drops and taken as tablets, and the patient recovered well within about a month.

Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights from Candida albicans and Fusarium falciforme

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This study compared how two types of fungi invade the cornea of the eye. Candida albicans, a yeast, stayed localized to where it entered the eye and was easier to control surgically. In contrast, Fusarium falciforme, a mold, spread aggressively throughout the entire cornea and was much harder to treat. Understanding these different invasion patterns helps explain why some fungal eye infections are more difficult to manage than others.

First report of Stemphylium lycopersici keratitis, a complex corneal infection case

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A 66-year-old man developed a severe corneal infection from a stone chip injury that didn’t improve with standard antibiotics. Doctors discovered the infection was caused by a rare plant fungus called Stemphylium lycopersici, combined with a herpes virus. Using advanced genetic testing (mNGS) to identify the exact pathogens, they prescribed targeted antifungal and antiviral medications along with a corneal transplant, successfully healing the infection and preserving his vision.

A case of corneal infection with Clonostachys rosea

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A 53-year-old patient developed a corneal infection caused by a fungus called Clonostachys rosea, likely from an eye injury. This is the first reported case of this particular fungus infecting the cornea. The infection was successfully treated with antifungal eye drops and oral medications, with the ulcer healing into a scar within one month.

Research Topic: corneal infection