Research Topic: clinical safety

Psychedelic iatrogenic structural dissociation: an exploratory hypothesis on dissociative risks in psychedelic use

This paper explores potential risks of psychedelic use in people who have experienced trauma, proposing that psychedelics might reactivate unprocessed traumatic memories and cause psychological instability. The authors suggest that while psychedelics show promise for treating depression and PTSD, people with trauma histories need careful screening and support before, during, and after use. They recommend body-focused therapies and strong social support to help safely integrate traumatic material that might surface during psychedelic experiences.

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Psilocybin therapy and anorexia nervosa: a narrative review of safety considerations for researchers and clinicians

This review examines the safety of psilocybin therapy for treating anorexia nervosa, a serious eating disorder with limited treatment options. The authors analyze how psilocybin’s common side effects (like increased heart rate, nausea, and dizziness) interact with medical complications already present in people with anorexia. Based on early clinical trials, they conclude that psilocybin can be safely used in this population with proper medical screening and monitoring protocols tailored to their specific vulnerabilities.

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